Gastric bilirubin monitoring to assess duodenogastric reflux

Duodenogastric reflux (DGR) was assessed with 24-hour gastric bilirubin monitoring in 345 patients (219 men; 49 +/- 13 years) with foregut symptoms and 41 healthy subjects (24 men, 28 +/- 5 years). Bilirubin exposure was measured as percent time above absorbance level 0.25 and excessive DGR was defi...

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Bibliographic Details
Published in:Digestive diseases and sciences 2002-12, Vol.47 (12), p.2769-2774
Main Authors: FEIN, Martin, FREYS, Stephan M, SAILER, Marco, MAROSKE, Jörn, TIGGES, Harald, FUCHS, Karl-Hermann
Format: Article
Language:English
Subjects:
Adult
Bilirubin - analysis
Biological and medical sciences
Digestive system
Duodenogastric Reflux - diagnosis
Duodenogastric Reflux - metabolism
Dyspepsia - metabolism
Female
Gastric Mucosa - metabolism
Humans
Investigative techniques, diagnostic techniques (general aspects)
Male
Medical sciences
Middle Aged
Monitoring, Physiologic
Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques
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Summary:Duodenogastric reflux (DGR) was assessed with 24-hour gastric bilirubin monitoring in 345 patients (219 men; 49 +/- 13 years) with foregut symptoms and 41 healthy subjects (24 men, 28 +/- 5 years). Bilirubin exposure was measured as percent time above absorbance level 0.25 and excessive DGR was defined above the 95th percentile of normal values (>24.8%). DGR was highest following Billroth II gastric resection (60 +/- 24%, N = 15). Patients after cholecystectomy (28 +/- 25%, N = 25), patients with gastroesophageal reflux disease (24 +/- 24%, N = 199), and patients with nonulcer dyspepsia (23 +/- 21%, N = 61) had a significantly higher exposure to DGR than healthy subjects (7 +/- 8%, P < 0.0001). In conclusion, gastric bilirubin monitoring is useful for the assessment of DGR specifically in symptomatic patients following gastric resection. Increased amounts of DGR may further be of clinical importance in patients with reflux disease or nonulcer dyspepsia and following cholecystectomy.
ISSN:0163-2116
1573-2568
DOI:10.1023/a:1021069508731