Effects of duodenal seal oil administration in patients with inflammatory bowel disease

Long‐chain n‐3 PUFA in fish oil have modulating effects on inflammatory responses. The aim of this open pilot study was to investigate whether duodenal seal oil administration would benefit patients with inflammatory bowel disease (IBD). Seal oil (10 mL) was administered three times a day directly i...

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Bibliographic Details
Published in:Lipids 2002-10, Vol.37 (10), p.935-940
Main Authors: Arslan, Gülen, Brunborg, Linn Anne, Frøyland, Livar, Brun, Johan G., Valen, Merete, Berstad, Arnold
Format: Article
Language:English
Subjects:
Administration, Oral
Animals
Arthralgia - drug therapy
Chronic Disease
Colitis - drug therapy
Crohn Disease - drug therapy
Duodenum - drug effects
Duodenum - metabolism
Fatty Acids, Unsaturated - blood
Female
Fish oils
Humans
Inflammatory bowel disease
Inflammatory Bowel Diseases - blood
Inflammatory Bowel Diseases - drug therapy
Longitudinal Studies
Male
Oils - administration & dosage
Oils - chemistry
Oils - pharmacology
Oils - therapeutic use
Pain
Peroxidation
Seals, Earless
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Summary:Long‐chain n‐3 PUFA in fish oil have modulating effects on inflammatory responses. The aim of this open pilot study was to investigate whether duodenal seal oil administration would benefit patients with inflammatory bowel disease (IBD). Seal oil (10 mL) was administered three times a day directly into the distal part of the duodenum via a nasoduodenal feeding tube for 10 d in 10 patients, 5 of whom had Crohn's disease and 5 ulcerative colitis. Nine of the 10 patients suffered from IBD‐associated joint pain. Various parameters of disease activity and FA incorporation in tissues were analyzed before and after treatment. Following seal oil therapy, joint pain index, disease activity, and serum cholesterol level were significantly decreased, whereas the n‐3 to n‐6 ratio both in intestinal biopsies and blood was significantly increased. Measures of calprotectin concentration in gut lavage fluid, intestinal permeability, and lipid peroxidation were not significantly changed. The results suggest positive effects of seal oil in patients with IBD, especially on IBD‐associated joint pain. Further controlled studies are warranted.
ISSN:0024-4201
1558-9307
DOI:10.1007/s11745-006-0983-2