Thromboprophylaxis throughout pregnancy in women with previous history of recurrent miscarriages of unknown aetiology

The purpose of this prospective preliminary clinical study was to assess the efficacy of thromboprophylaxis throughout pregnancy in women with a history of unexplained first trimester recurrent miscarriages. From the 53 patients originally assigned to the study 15 were excluded. The remaining 38 wer...

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Bibliographic Details
Published in:Clinical and experimental obstetrics & gynecology 2002, Vol.29 (4), p.267-270
Main Authors: Tzafettas, J, Mamopoulos, A, Anapliotis, A, Loufopoulos, A, Psarra, A, Klearchou, N, Mamopoulos, M
Format: Article
Language:English
Subjects:
Abortion, Habitual - prevention & control
Adult
Anticoagulants - administration & dosage
Anticoagulants - therapeutic use
Aspirin - administration & dosage
Aspirin - therapeutic use
Cohort Studies
Drug Administration Schedule
Female
Heparin, Low-Molecular-Weight - administration & dosage
Heparin, Low-Molecular-Weight - therapeutic use
Humans
Pregnancy
Pregnancy Complications, Hematologic - prevention & control
Pregnancy Trimester, First
Prospective Studies
Thrombophilia - prevention & control
Treatment Outcome
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Summary:The purpose of this prospective preliminary clinical study was to assess the efficacy of thromboprophylaxis throughout pregnancy in women with a history of unexplained first trimester recurrent miscarriages. From the 53 patients originally assigned to the study 15 were excluded. The remaining 38 were treated with low molecular weight heparin (LMWH-natroparine calcium 0.3 ml twice daily) and low dose aspirin from the day the fetal heart motion was detected until the 37th week or earlier at the onset of premature labor. Among the patients treated (n = 38) thrombophilia screening was positive in 16 patients and in the remaining 22 no causative factor was detected. The overall success rate (viable pregnancy > or = 24 weeks) was 92.2% with no significant difference between patients with positive or negative thrombophilia screening. The most significant complications were: preeclampsia (21%), IUGR (26%), placenta abruptio (5.2%), injection site haematoma (44%) and skin reaction (15.7%). No abnormal bleeding was observed during vaginal or caesarean section. The results of this study suggest that thromboprophylaxis during pregnancy, which has already been successfully tried in patients with recurrent miscarriages with a causative factor, may be similarly effective in patients with such a pregnancy complication but of unknown aetiology.
ISSN:0390-6663