Evolutionary ideas about genetically manipulated mosquitoes and malaria control

The release of mosquitoes that are genetically manipulated to destroy the malaria parasite Plasmodium falciparum is being considered as a possible method for malaria control. Hopes for this have been raised by the identification of genes involved in the mosquito's immune response and by advance...

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Bibliographic Details
Published in:Trends in parasitology 2003, Vol.19 (1), p.32-38
Main Authors: Boëte, Christophe, Koella, Jacob C.
Format: Article
Language:English
Subjects:
Animals
Anopheles - genetics
Anopheles - immunology
Biological and medical sciences
Biological Evolution
Biotechnology
Cost-Benefit Analysis
Decision Support Techniques
DNA Transposable Elements
Fundamental and applied biological sciences. Psychology
Genetic engineering
Genetic technics
Insect Vectors
Malaria, Falciparum - prevention & control
Medically important nuisances and vectors, pests of stored products and materials: population survey and control
Methods. Procedures. Technologies
Plasmodium falciparum - genetics
Plasmodium falciparum - immunology
Transgenic animals
Transgenic animals and transgenic plants
Vectors. Intermediate hosts
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Summary:The release of mosquitoes that are genetically manipulated to destroy the malaria parasite Plasmodium falciparum is being considered as a possible method for malaria control. Hopes for this have been raised by the identification of genes involved in the mosquito's immune response and by advances in the tools required to transform mosquitoes. But, will such genes be able to spread in natural populations? What will their impact be on epidemiology of the disease? This article attempts to give some answers to these questions by reviewing some theoretical and empirical considerations underlying the evolutionary epidemiology of genetic manipulation and refractoriness.
ISSN:1471-4922
1471-5007
DOI:10.1016/S1471-4922(02)00003-X