Reactivation of insulin-like growth factor II during hepatocarcinogenesis in transgenic mice suggests a role in malignant growth

We have studied the expression of insulin-like growth factor II (IGF-II) during hepatocarcinogenesis in four independent transgenic mouse lines. In all four lines liver-directed transgene expression induces a stepwise and relatively synchronized tumorigenesis. IGF-II reexpression occurs in all four...

Full description

Saved in:
Bibliographic Details
Published in:Cancer research (Baltimore) 1992-05, Vol.52 (9), p.2549-2556
Main Authors: SCHIRMACHER, P, HELD, W. A, CHISARI, F. V, RUSTUM, Y, ROGLER, C. E
Format: Article
Language:English
Subjects:
Animal tumors. Experimental tumors
Animals
Antigens, Polyomavirus Transforming - metabolism
Biological and medical sciences
Blotting, Northern
Cell Division
Experimental digestive system and abdominal tumors
Histones - metabolism
Insulin-Like Growth Factor II - metabolism
Liver - metabolism
Liver Neoplasms, Experimental - etiology
Liver Neoplasms, Experimental - metabolism
Liver Neoplasms, Experimental - pathology
Medical sciences
Mice
RNA, Messenger - metabolism
S Phase
Tumors
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:We have studied the expression of insulin-like growth factor II (IGF-II) during hepatocarcinogenesis in four independent transgenic mouse lines. In all four lines liver-directed transgene expression induces a stepwise and relatively synchronized tumorigenesis. IGF-II reexpression occurs in all four lines irrespective of the mechanism of tumor induction. Reexpression is chronologically associated with late progression steps toward hepatocellular carcinoma and correlated with the respective tumor progression rate in each line. IGF-II activation is focal and topographically associated with high replicative activity. IGF-II mRNAs in hepatocellular carcinomas show similarities to the expression pattern in fetal liver, and a M(r) 15,000 IGF-II polypeptide accumulates intracellularly in distinct cytoplasmic preferentially perinuclear compartments. These data indicate that IGF-II reexpression is a marker for progression to hepatocellular carcinoma and may contribute to hepatocarcinogenesis via an autocrine mechanism.
ISSN:0008-5472
1538-7445