The leptin, a new hormone of adipose tissue: clinical findings and perspectives in geriatrics

• Published in: Archives of gerontology and geriatrics 2002-02, Vol.34 (1), p.47-54
• Main Authors: Maugeri, D., Bonanno, M.R., Speciale, S., Santangelo, A., Lentini, A., Russo, M.S., Calanna, A., Malaguarnera, M., Motta, M., Testai’, M., Panebianco, P.
• Format: Article
• Language: English
• Subjects: Adipocytes; Genetic regulation of obesity; Leptin in aging; Obesity
• ISSN: 0167-4943; 1872-6976
• DOI: 10.1016/S0167-4943(01)00195-9

Obesity has gained a great importance during the last decades, and this fact stimulated numerous studies regarding the genetic causes of this disease. A recently discovered new molecule, called leptin, raised a wide interest. It is a product of the adipocytes, it exerts inhibitory effects on the center of appetite and increases the energy expenditure of the organism. The present study evaluated blood leptin levels in 57 elderly subjects and searched for eventual correlations between this parameter and the age, the body mass index (BMI), the fat body mass (fat %), the waist (W) and hip (H) circumference, as well as the ratio (R) of these latter two values (WHR). Blood leptin levels do not correlate with age, body height and the WHR, but display significant positive correlations with the body weight, the BMI, the fat%, the W, H and WHR. A deeper knowledge on leptin and the correlations of this hormone with other body parameters might be helpful in a better understanding of several pathogenetic mecharnams related to aging and involved in a deterioration of the quality of life in elderly, like multiple atherosclerotic and metabolic diseases (diabetes, dyslipidemias).