Association of diabetes mellitus with abnormal heart rate recovery in patients without known coronary artery disease

Autonomic neuropathy is a common complication of diabetes mellitus, particularly in patients using insulin. The presence of subclinical or clinical autonomic dysfunction is associated with increased mortality. Heart rate variability, a measure of sympathetic and parasympathetic influences on the hea...

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Bibliographic Details
Published in:The American journal of cardiology 2003, Vol.91 (1), p.108-111
Main Authors: Seshadri, Niranjan, Acharya, Naveen, Lauer, Michael S
Format: Article
Language:English
Subjects:
Associated diseases and complications
Autonomic Nervous System - physiopathology
Biological and medical sciences
Blood Glucose - analysis
Chi-Square Distribution
Diabetes
Diabetes Mellitus - diagnosis
Diabetes Mellitus - physiopathology
Diabetes. Impaired glucose tolerance
Diagnostic tests
Endocrine pancreas. Apud cells (diseases)
Endocrinopathies
Exercise Test
Female
Glucose
Heart
Heart Rate - physiology
Humans
Male
Medical sciences
Middle Aged
Mortality
Prospective Studies
Regression Analysis
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Summary:Autonomic neuropathy is a common complication of diabetes mellitus, particularly in patients using insulin. The presence of subclinical or clinical autonomic dysfunction is associated with increased mortality. Heart rate variability, a measure of sympathetic and parasympathetic influences on the heart, is reduced in the presence of autonomic dysfunction that is related to hyperglycemia. Another measure of parasympathetic function is heart rate recovery, an easily obtained measure derived from routinely graded exercise testing. An attenuated heart rate recovery has been shown to predict mortality. There are few data on the association of blood glucose levels with heart rate recovery. We aimed to determine if increasing blood glucose concentration and/or diabetes mellitus are independently associated with an abnormal heart rate recovery after graded treadmill exercise testing in a cohort of patients with no known coronary artery disease.
ISSN:0002-9149
1879-1913
DOI:10.1016/S0002-9149(02)03014-X