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Glutathione S-transferase M1, T1, and P1 Polymorphisms and Parkinson's Disease
Oxidative stress is widely thought to contribute significantly to the pathogenesis Parkinson's disease (PD). Given the role of glutathione S-transferases (GSTs) in the conjugation of electrophiles and protection against reactive oxygen species, genes encoding the GSTs have been considered candi...
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Published in: | Neuroscience letters 2003-01, Vol.337 (1), p.5-8 |
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Main Authors: | , , , , , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
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Summary: | Oxidative stress is widely thought to contribute significantly to the pathogenesis Parkinson's disease (PD). Given the role of glutathione S-transferases (GSTs) in the conjugation of electrophiles and protection against reactive oxygen species, genes encoding the GSTs have been considered candidates for association studies of PD. We tested for associations between genotypes of
GSTM1(homozygous deletion vs. non-deleted),
GSTT1(homozygous deletion vs. non-deleted), and
GSTP1 (Ile104Val and Ala113Val) and PD in a case-control study of 214 idiopathic PD cases and 330 age- and gender-matched, unrelated controls of Caucasian ethnicity. No significant associations with any of the
GST genotypes were observed. However, there was a marginally significant difference in the distribution of
GSTP1 104 genotypes between cases and controls (
P=0.07), with an excess of Ile104Val heterozygotes found among cases (odds ratio (OR)=1.43; 95% Confidence Interval (CI): 0.98–2.08). This difference in the genotype distribution was strongest among smokers (OR for heterozygote=1.92; 95% CI: 1.12–3.29) versus non-smokers and among males (OR for heterozygote=1.99; 95% CI: 1.24–3.19) versus females. The distribution of
GSTP1 Ile104Val and Ala113Val haplotypes did not differ between cases and controls. Taken together, these results suggest a potentially minor role of
GSTP1 in PD, but do not give evidence for associations with either
GSTM1 or
GSTT1. |
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ISSN: | 0304-3940 1872-7972 |
DOI: | 10.1016/S0304-3940(02)01286-7 |