A comparison of the fragmentation thresholds and inertial cavitation doses of different ultrasound contrast agents

• Published in: The Journal of the Acoustical Society of America 2003-01, Vol.113 (1), p.643-651
• Main Authors: Chen, Wen-Shiang, Matula, Thomas J, Brayman, Andrew A, Crum, Lawrence A
• Format: Article
• Language: English
• Subjects: Air Pressure; Albumins - pharmacokinetics; Contrast Media - pharmacokinetics; Ferric Compounds - pharmacokinetics; Fluorocarbons - pharmacokinetics; Humans; Iron - pharmacokinetics; Microspheres; Oxides - pharmacokinetics; Particle Size; Space life sciences; Structure-Activity Relationship; Ultrasonography
• ISSN: 0001-4966; 1520-8524
• DOI: 10.1121/1.1529667

Contrast bubble destruction is important in several new diagnostic and therapeutic applications. The pressure threshold of destruction is determined by the shell material, while the propensity for of the bubbles to undergo inertial cavitation (IC) depends both on the gas and shell properties of the ultrasound contrast agent (UCA). The ultrasonic fragmentation thresholds of three specific UCAs (Optison, Sonazoid, and biSpheres), each with different shell and gas properties, were determined under various acoustic conditions. The acoustic emissions generated by the agents, or their derivatives, characteristic of IC after fragmentation, was also compared, using cumulated broadband-noise emissions (IC "dose"). Albumin-shelled Optison and surfactant-shelled Sonazoid had low fragmentation thresholds (mean = 0.13 and 0.15 MPa at 1.1 MHz, 0.48 and 0.58 MPa at 3.5 MHz, respectively), while polymer-shelled biSpheres had a significant higher threshold (mean = 0.19 and 0.23 MPa at 1.1 MHz, 0.73 and 0.96 MPa for thin- and thick-shell biSpheres at 3.5 MHz, respectively, p