A comparison of the effects of fluvoxamine and amitriptyline on autonomic functions in healthy volunteers

We have compared the effects of single oral doses of fluvoxamine (50 mg and 100 mg), amitriptyline (50 mg and 100 mg), and placebo on some autonomic functions in ten healthy volunteers, using a balanced, double-blind, crossover design. Amitriptyline significantly reduced salivation, the miosis evoke...

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Bibliographic Details
Published in:European journal of clinical pharmacology 1992-05, Vol.42 (5), p.529-533
Main Authors: FLETT, S. R, SZABADI, E, BRADSHAW, C. M
Format: Article
Language:English
Subjects:
Administration, Oral
Adult
Amitriptyline - administration & dosage
Amitriptyline - pharmacology
Autonomic Nervous System - drug effects
Autonomic Nervous System - physiology
Biological and medical sciences
Blood Pressure - drug effects
Carbachol - antagonists & inhibitors
Double-Blind Method
Fluvoxamine - administration & dosage
Fluvoxamine - pharmacology
Humans
Male
Medical sciences
Neuropharmacology
Pharmacology. Drug treatments
Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease)
Psychology. Psychoanalysis. Psychiatry
Psychopharmacology
Pupil - drug effects
Receptors, Muscarinic
Salivation - drug effects
Sweat Glands - drug effects
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Summary:We have compared the effects of single oral doses of fluvoxamine (50 mg and 100 mg), amitriptyline (50 mg and 100 mg), and placebo on some autonomic functions in ten healthy volunteers, using a balanced, double-blind, crossover design. Amitriptyline significantly reduced salivation, the miosis evoked by locally applied pilocarpine, and the sweat secretion evoked by locally applied carbachol. Fluvoxamine also significantly attenuated carbachol-evoked sweat gland activity, although to a smaller degree than amitriptyline; fluvoxamine did not significantly alter salivation or pilocarpine-evoked miosis. Neither treatment significantly altered the miotic responses evoked by brief light stimuli. Heart rate and blood pressure were not greatly affected by either treatment, although the fall in heart rate (erect posture) with placebo was significantly reduced by amitriptyline (100 mg). The results suggest that fluvoxamine has some anti-muscarinic activity in man, but is considerably less potent in this respect than amitriptyline.
ISSN:0031-6970
1432-1041
DOI:10.1007/BF00314863