Vitamin D receptor gene polymorphism BsmI is not associated with the prevalence and severity of CAD in a large-scale angiographic cohort of 3441 patients

Background Recent studies found a relationship between Vitamin D and atherosclerosis. A common genetic polymorphism of the Vitamin D receptor (VDR) has been associated with coronary artery disease (CAD) in small study populations. To assess its influence on the prevalence and severity of CAD we stud...

Full description

Saved in:
Bibliographic Details
Published in:European journal of clinical investigation 2003-02, Vol.33 (2), p.106-109
Main Authors: Ortlepp, J. R., Von Korff, A., Hanrath, P., Zerres, K., Hoffmann, R.
Format: Article
Language:English
Subjects:
Aged
CAD
Cardiovascular risk factors
Cohort Studies
Coronary Angiography
Coronary Disease - diagnostic imaging
Coronary Disease - epidemiology
Coronary Disease - genetics
Female
Genetic Predisposition to Disease
Genotype
Germany - epidemiology
Humans
Male
Middle Aged
Phenotype
polymorphism
Polymorphism, Genetic
Receptors, Calcitriol - genetics
Risk Factors
Vitamin D receptor
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background Recent studies found a relationship between Vitamin D and atherosclerosis. A common genetic polymorphism of the Vitamin D receptor (VDR) has been associated with coronary artery disease (CAD) in small study populations. To assess its influence on the prevalence and severity of CAD we studied a large‐scale population. Methods A total of 3441 consecutive patients were referred for diagnostic coronary angiography. The BsmI Vitamin D receptor polymorphism was analyzed by polymerase chain reaction. Angiography was used to define phenotypes with clear coronary arteries (n = 775), coronary sclerosis (diameter stenosis < 50%; n = 579), CAD (diameter stenosis > 50% in at least one vessel; n = 1524). Patients with CAD at a young age (females aged less than 65 years, males aged less than 55 years; n = 563) were specially defined as premature CAD. The risk profile of traditional cardiovascular risk factors was obtained for every patient. Results The genotype frequencies of the VDR BsmI polymorphism did not differ between all four phenotypes (P = 0·756). The allele frequencies for the B allele were 0·43 vs. 0·44 vs. 0·42 vs. 0·45 in the four phenotypic groups (P = 0·827). All traditional cardiovascular risk factors (hypercholesterolaemia, smoking, hypertension, diabetes mellitus, severe obesity, male gender) were significantly (P 
ISSN:0014-2972
1365-2362
DOI:10.1046/j.1365-2362.2003.01124.x