Huntingtin distribution among striatal output neurons of normal rat brain

Huntingtin is the protein whose mutation leads to Huntington's disease (HD). The protein is heterogeneously distributed in the telencephalon, and not consistently correlated with cell vulnerability in HD [Fusco, F.R., Chen, Q., Lamoreaux, W.J., Figueredo-Cardenas, G., Jiao, Y., Coffman, J.A., S...

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Published in:Neuroscience letters 2003-03, Vol.339 (1), p.53-56
Main Authors: Fusco, Francesca R., Martorana, Alessandro, De March, Zena, Viscomi, Maria Teresa, Sancesario, Giuseppe, Bernardi, Giorgio
Format: Article
Language:English
Subjects:
Anatomy
Animals
Biological and medical sciences
Central nervous system
Corpus Striatum - cytology
Corpus Striatum - metabolism
Fundamental and applied biological sciences. Psychology
Globus Pallidus - cytology
Globus Pallidus - metabolism
Huntingtin
Huntingtin Protein
Huntington's disease
Male
Nerve Tissue Proteins - metabolism
Neurons - metabolism
Nuclear Proteins - metabolism
Rats
Receptors, Cannabinoid
Receptors, Dopamine D1 - metabolism
Receptors, Drug - metabolism
Striatal output neurons
Striatum
Substantia Nigra - cytology
Substantia Nigra - metabolism
Vertebrates: nervous system and sense organs
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Summary:Huntingtin is the protein whose mutation leads to Huntington's disease (HD). The protein is heterogeneously distributed in the telencephalon, and not consistently correlated with cell vulnerability in HD [Fusco, F.R., Chen, Q., Lamoreaux, W.J., Figueredo-Cardenas, G., Jiao, Y., Coffman, J.A., Surmeier, D.J., Honig, M.G., Carlock, L.R., and Reiner, A., J. Neurosci., 19 (1999) 1189-1202]. The aim of our study was to investigate a possible preferential distribution of huntingtin among the two main striatal output pathways, namely, the striatonigral and the striatopallidal circuit. Dual label immunofluorescence by means of confocal microscopy was used to detect the presence of huntingtin among striatal projection neurons identified by their cellular content of Substance P, Enkephalin, CB1 receptor, and D1a dopamine receptor. Our data showed that striatopallidal neurons co-containing SP and D1a [Surmeier, D.J., Song, W.J., and Yan, Z., J. Neurosci., 16 (1996) 6579-6591] co-localized with huntingtin in a higher proportion than striatonigral neurons.
ISSN:0304-3940
1872-7972
DOI:10.1016/S0304-3940(02)01474-X