Cerebral Microcirculatory Changes After Cerebral Embolization Induced by Glass Bead Injection in Rabbits

The authors investigated microcirculatory changes in cerebral embolization induced by an injection of glass beads (mesh size 20/400, 15 mg/body) using intravital microscopy and reflectance spectrophotometry in normal rabbits. Cerebral embolization with the glass bead injection reduced the inner diam...

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Bibliographic Details
Published in:Angiology 1992-08, Vol.43 (8), p.678-684
Main Authors: Nagano, Hiroshi, Suzuki, Tsunemasa, Hayashi, Motohide, Asano, Makishige
Format: Article
Language:English
Subjects:
6-Ketoprostaglandin F1 alpha - blood
Animals
Biological and medical sciences
Cerebrovascular Circulation - physiology
Embolization, Therapeutic
Female
Indomethacin - pharmacology
Medical sciences
Microcirculation - physiology
Microscopy
Microspheres
Models, Biological
Nervous system involvement in other diseases. Miscellaneous
Neurology
Photomicrography
Platelet Aggregation
Rabbits
Thromboxane B2 - blood
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Summary:The authors investigated microcirculatory changes in cerebral embolization induced by an injection of glass beads (mesh size 20/400, 15 mg/body) using intravital microscopy and reflectance spectrophotometry in normal rabbits. Cerebral embolization with the glass bead injection reduced the inner diameter of cerebral arterioles, the index of cerebral hemoglobin concentration (IHb), and the index of oxygen saturation (ISO2). Moreover, platelet aggregation rates and plasma levels of thromboxane B2 (TXB2) and 6-keto-prostaglandin F1α (6-keto-PGF1α) appreciably increased. During observation of the pial vasculature, "white bodies" became visible at the entrance of arteriolar branchings two to three minutes after the glass bead injection. After indomethacin administration (3 mg/kg, IV), they could not observe white bodies, and platelet aggregation rates were significantly reduced. The plasma levels of TXB2 and 6-keto-PGF1α were also significantly reduced. These findings suggest that glass beads do injury to the microvascular endothelial cells leading to development of white bodies, ie, "flying thrombi." Therefore, the cerebral microvascular embolization induced by the glass bead injection appears to be an experimental model for evaluating efficacy of remedies for the cerebral microcirculatory disorders.
ISSN:0003-3197
1940-1574
DOI:10.1177/000331979204300808