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Fast and single solid phase fluorescence spectroscopic batch procedure for (acetyl) salicylic acid determination in drug formulations
A solid phase fluorescence spectroscopic batch procedure for (acetyl) salicylic acid in drug formulations have been developed. The procedure is based on the sorption of salicylic acid (SA) on Sephadex DEAE A-25 anion exchanger gel (100 mg) by equilibration from an aqueous solution (10 or 25 ml) for...
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| Published in: | Journal of pharmaceutical and biomedical analysis 2003-03, Vol.31 (3), p.439-446 |
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| Main Authors: | , , |
| Format: | Article |
| Language: | English |
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| cites | cdi_FETCH-LOGICAL-c457t-32fbde535505a346318658edaaafce834fa1e0cd4a9d1c0e2cda19547d8c4bad3 |
| container_end_page | 446 |
| container_issue | 3 |
| container_start_page | 439 |
| container_title | Journal of pharmaceutical and biomedical analysis |
| container_volume | 31 |
| creator | Ortega Algar, S Ramos Martos, N Molina Dı́az, A |
| description | A solid phase fluorescence spectroscopic batch procedure for (acetyl) salicylic acid in drug formulations have been developed. The procedure is based on the sorption of salicylic acid (SA) on Sephadex DEAE A-25 anion exchanger gel (100 mg) by equilibration from an aqueous solution (10 or 25 ml) for 5 min; the equilibrated gel is transferred into an 1 mm quartz cell and the native fluorescence of SA sorbed on it is directly measured (
λ
ex=297 nm;
λ
em=405 nm). Good linearity was found in the 10–200 and 5–100 μg l
−1 ranges (for 10 and 25 ml sample volume, respectively) with R.S.D. (%) of 2.8 and 1.1. The procedure was successfully applied to the determination of acetyl salicylic acid (ASA) in drug formulations after alkaline hydrolysis to yield SA. |
| doi_str_mv | 10.1016/S0731-7085(02)00719-7 |
| format | article |
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λ
ex=297 nm;
λ
em=405 nm). Good linearity was found in the 10–200 and 5–100 μg l
−1 ranges (for 10 and 25 ml sample volume, respectively) with R.S.D. (%) of 2.8 and 1.1. The procedure was successfully applied to the determination of acetyl salicylic acid (ASA) in drug formulations after alkaline hydrolysis to yield SA.</description><identifier>ISSN: 0731-7085</identifier><identifier>EISSN: 1873-264X</identifier><identifier>DOI: 10.1016/S0731-7085(02)00719-7</identifier><identifier>PMID: 12615230</identifier><identifier>CODEN: JPBADA</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>(Acetyl) salicylic acid ; Algorithms ; Analysis ; Anti-Inflammatory Agents, Non-Steroidal - analysis ; Aspirin - analysis ; Biological and medical sciences ; Caffeine - chemistry ; Capsules ; Chromatography, DEAE-Cellulose ; Chromatography, Ion Exchange ; Codeine - chemistry ; Drug Combinations ; Drug formulations ; General pharmacology ; Hydrogen-Ion Concentration ; Indicators and Reagents ; Medical sciences ; Pharmacology. Drug treatments ; Solid-phase fluorimetry ; Spectrometry, Fluorescence ; Tablets</subject><ispartof>Journal of pharmaceutical and biomedical analysis, 2003-03, Vol.31 (3), p.439-446</ispartof><rights>2003 Elsevier Science B.V.</rights><rights>2003 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c457t-32fbde535505a346318658edaaafce834fa1e0cd4a9d1c0e2cda19547d8c4bad3</citedby><cites>FETCH-LOGICAL-c457t-32fbde535505a346318658edaaafce834fa1e0cd4a9d1c0e2cda19547d8c4bad3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14642190$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12615230$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ortega Algar, S</creatorcontrib><creatorcontrib>Ramos Martos, N</creatorcontrib><creatorcontrib>Molina Dı́az, A</creatorcontrib><title>Fast and single solid phase fluorescence spectroscopic batch procedure for (acetyl) salicylic acid determination in drug formulations</title><title>Journal of pharmaceutical and biomedical analysis</title><addtitle>J Pharm Biomed Anal</addtitle><description>A solid phase fluorescence spectroscopic batch procedure for (acetyl) salicylic acid in drug formulations have been developed. The procedure is based on the sorption of salicylic acid (SA) on Sephadex DEAE A-25 anion exchanger gel (100 mg) by equilibration from an aqueous solution (10 or 25 ml) for 5 min; the equilibrated gel is transferred into an 1 mm quartz cell and the native fluorescence of SA sorbed on it is directly measured (
λ
ex=297 nm;
λ
em=405 nm). Good linearity was found in the 10–200 and 5–100 μg l
−1 ranges (for 10 and 25 ml sample volume, respectively) with R.S.D. (%) of 2.8 and 1.1. The procedure was successfully applied to the determination of acetyl salicylic acid (ASA) in drug formulations after alkaline hydrolysis to yield SA.</description><subject>(Acetyl) salicylic acid</subject><subject>Algorithms</subject><subject>Analysis</subject><subject>Anti-Inflammatory Agents, Non-Steroidal - analysis</subject><subject>Aspirin - analysis</subject><subject>Biological and medical sciences</subject><subject>Caffeine - chemistry</subject><subject>Capsules</subject><subject>Chromatography, DEAE-Cellulose</subject><subject>Chromatography, Ion Exchange</subject><subject>Codeine - chemistry</subject><subject>Drug Combinations</subject><subject>Drug formulations</subject><subject>General pharmacology</subject><subject>Hydrogen-Ion Concentration</subject><subject>Indicators and Reagents</subject><subject>Medical sciences</subject><subject>Pharmacology. Drug treatments</subject><subject>Solid-phase fluorimetry</subject><subject>Spectrometry, Fluorescence</subject><subject>Tablets</subject><issn>0731-7085</issn><issn>1873-264X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><recordid>eNqFkcuKFDEUQIMoTk_rJyjZKDOL0qSS1GM1yDCjwoALFdyF2ze3ZiKph0mV0B_gf5vqbpylixBIzn2dy9grKd5JIav3X0WtZFGLxlyI8lKIWrZF_YRtZFOroqz0j6ds8w85Y-cp_RRCGNnq5-xMlpU0pRIb9ucW0sxhcDz54T4QT2Pwjk8PkIh3YRkjJaQB88dEOMcx4Th55DuY8YFPcURyS8zoGPkFIM37cMkTBI_7fDhgTuZoptj7AWY_DtwP3MXlfo3ol3B4Sy_Ysw5Copene8u-3958u_5U3H35-Pn6w12B2tRzocpu58goY4QBpSslm8o05ACgQ2qU7kCSQKehdRIFlehAtkbXrkG9A6e27O0xb27810Jptr3P44UAA41LsrUSVVNqlUFzBDFPnCJ1doq-h7i3UtjVvz34t6tcK0p78J_Dt-z1qcCy68k9Rp2EZ-DNCYCEELoIA_r0yOlKl7JduasjR1nHb0_RJvTrHpyPeQ_Wjf4_rfwFDTOlog</recordid><startdate>20030310</startdate><enddate>20030310</enddate><creator>Ortega Algar, S</creator><creator>Ramos Martos, N</creator><creator>Molina Dı́az, A</creator><general>Elsevier B.V</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20030310</creationdate><title>Fast and single solid phase fluorescence spectroscopic batch procedure for (acetyl) salicylic acid determination in drug formulations</title><author>Ortega Algar, S ; Ramos Martos, N ; Molina Dı́az, A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c457t-32fbde535505a346318658edaaafce834fa1e0cd4a9d1c0e2cda19547d8c4bad3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>(Acetyl) salicylic acid</topic><topic>Algorithms</topic><topic>Analysis</topic><topic>Anti-Inflammatory Agents, Non-Steroidal - analysis</topic><topic>Aspirin - analysis</topic><topic>Biological and medical sciences</topic><topic>Caffeine - chemistry</topic><topic>Capsules</topic><topic>Chromatography, DEAE-Cellulose</topic><topic>Chromatography, Ion Exchange</topic><topic>Codeine - chemistry</topic><topic>Drug Combinations</topic><topic>Drug formulations</topic><topic>General pharmacology</topic><topic>Hydrogen-Ion Concentration</topic><topic>Indicators and Reagents</topic><topic>Medical sciences</topic><topic>Pharmacology. Drug treatments</topic><topic>Solid-phase fluorimetry</topic><topic>Spectrometry, Fluorescence</topic><topic>Tablets</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ortega Algar, S</creatorcontrib><creatorcontrib>Ramos Martos, N</creatorcontrib><creatorcontrib>Molina Dı́az, A</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of pharmaceutical and biomedical analysis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ortega Algar, S</au><au>Ramos Martos, N</au><au>Molina Dı́az, A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Fast and single solid phase fluorescence spectroscopic batch procedure for (acetyl) salicylic acid determination in drug formulations</atitle><jtitle>Journal of pharmaceutical and biomedical analysis</jtitle><addtitle>J Pharm Biomed Anal</addtitle><date>2003-03-10</date><risdate>2003</risdate><volume>31</volume><issue>3</issue><spage>439</spage><epage>446</epage><pages>439-446</pages><issn>0731-7085</issn><eissn>1873-264X</eissn><coden>JPBADA</coden><abstract>A solid phase fluorescence spectroscopic batch procedure for (acetyl) salicylic acid in drug formulations have been developed. The procedure is based on the sorption of salicylic acid (SA) on Sephadex DEAE A-25 anion exchanger gel (100 mg) by equilibration from an aqueous solution (10 or 25 ml) for 5 min; the equilibrated gel is transferred into an 1 mm quartz cell and the native fluorescence of SA sorbed on it is directly measured (
λ
ex=297 nm;
λ
em=405 nm). Good linearity was found in the 10–200 and 5–100 μg l
−1 ranges (for 10 and 25 ml sample volume, respectively) with R.S.D. (%) of 2.8 and 1.1. The procedure was successfully applied to the determination of acetyl salicylic acid (ASA) in drug formulations after alkaline hydrolysis to yield SA.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>12615230</pmid><doi>10.1016/S0731-7085(02)00719-7</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0731-7085 |
| ispartof | Journal of pharmaceutical and biomedical analysis, 2003-03, Vol.31 (3), p.439-446 |
| issn | 0731-7085 1873-264X |
| language | eng |
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| source | ScienceDirect Journals |
| subjects | (Acetyl) salicylic acid Algorithms Analysis Anti-Inflammatory Agents, Non-Steroidal - analysis Aspirin - analysis Biological and medical sciences Caffeine - chemistry Capsules Chromatography, DEAE-Cellulose Chromatography, Ion Exchange Codeine - chemistry Drug Combinations Drug formulations General pharmacology Hydrogen-Ion Concentration Indicators and Reagents Medical sciences Pharmacology. Drug treatments Solid-phase fluorimetry Spectrometry, Fluorescence Tablets |
| title | Fast and single solid phase fluorescence spectroscopic batch procedure for (acetyl) salicylic acid determination in drug formulations |
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