Influenza-virus-induced signaling cascades: targets for antiviral therapy?

Influenza viruses continue to pose a severe threat worldwide, causing thousands of deaths and an enormous economic loss every year. The major problem in fighting influenza is the high genetic variability of the virus, resulting in the rapid formation of variants that escape the acquired immunity aga...

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Bibliographic Details
Published in:Trends in molecular medicine 2003-02, Vol.9 (2), p.46-52
Main Authors: Ludwig, Stephan, Planz, Oliver, Pleschka, Stephan, Wolff, Thorsten
Format: Article
Language:English
Subjects:
Antiviral Agents - pharmacology
Humans
MAP Kinase Signaling System - genetics
Mitogen-Activated Protein Kinases - antagonists & inhibitors
Mitogen-Activated Protein Kinases - drug effects
NF-kappa B - metabolism
Orthomyxoviridae - drug effects
Orthomyxoviridae - genetics
Orthomyxoviridae - metabolism
Protein Kinase C - metabolism
Viral Nonstructural Proteins - metabolism
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Summary:Influenza viruses continue to pose a severe threat worldwide, causing thousands of deaths and an enormous economic loss every year. The major problem in fighting influenza is the high genetic variability of the virus, resulting in the rapid formation of variants that escape the acquired immunity against previous virus strains, or have resistance to antiviral agents. Every virus depends on its host cell and, hence, cellular functions that are essential for viral replication might be suitable targets for antiviral therapy. As a result, intracellular signaling cascades induced by the virus, in particular mitogen-activated protein kinase pathways, have recently come into focus.
ISSN:1471-4914
1471-499X
DOI:10.1016/S1471-4914(02)00010-2