Intramedullary Hemangioblastoma in a Dog

A 6-year-old male Pointer dog was presented with a 4-week history of progressive hind-limb stiffness. Magnetic resonance imaging demonstrated a focal intramedullary lesion at T1 level with a pattern of ring contrast enhancement. At necropsy, a circumscribed intramedullary reddish-gray tumor was obse...

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Bibliographic Details
Published in:Veterinary pathology 2003-01, Vol.40 (1), p.91-94
Main Authors: Cantile, C., Baroni, M., Tartarelli, C. L., Campani, D., Salvadori, C., Arispici, M.
Format: Article
Language:English
Subjects:
Animals
Dog Diseases - pathology
Dog Diseases - surgery
Dogs
Fatal Outcome
Hemangioblastoma - pathology
Hemangioblastoma - surgery
Hemangioblastoma - veterinary
Immunohistochemistry - veterinary
Magnetic Resonance Imaging - veterinary
Male
Spinal Cord Neoplasms - pathology
Spinal Cord Neoplasms - surgery
Spinal Cord Neoplasms - veterinary
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Summary:A 6-year-old male Pointer dog was presented with a 4-week history of progressive hind-limb stiffness. Magnetic resonance imaging demonstrated a focal intramedullary lesion at T1 level with a pattern of ring contrast enhancement. At necropsy, a circumscribed intramedullary reddish-gray tumor was observed. Microscopically, the tumor was composed of thin-walled capillaries lined by endothelial cells and separated by pleomorphic cells (stromal cells) with a moderate degree of anisokaryosis. Immunohistochemically, the endothelial cells were positive for factor VIII–related antigen and the stromal cells were positive for neuron-specific enolase and vimentin. GFAP-positive astrocytes were occasionally observed within the tumor. Both endothelial and stromal cells were negative for synaptophysin, S-100 protein, pankeratin, smooth muscle actin, CD34, CD68, α1-antichymotrypsin, and lysozyme. The tumor showed considerable morphologic and immunohistochemical similarities with human hemangioblastoma, and hence the inclusion of this tumor type within the primary neoplasms of the canine central nervous system is suggested.
ISSN:0300-9858
1544-2217
DOI:10.1354/vp.40-1-91