Ocular hypotensive effects of cholinergic and adrenergic drugs may be influenced by prostaglandins E2 in the human and rabbit eye

Increased PGE2 production by the iris and ciliary body regulate intraocular pressure (IOP) in vivo. Various cholinergic and adrenergic compounds are traditionally used as antiglaucoma drugs, and their effect on IOP reduction is antagonised by cyclooxygenase inhibitors, indicating a role for eicosano...

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Bibliographic Details
Published in:European journal of ophthalmology 2003, Vol.13 (1), p.18-23
Main Authors: KAPLAN-MESSAS, A, NAVEH, N, AVNI, I, MARSHALL, J
Format: Article
Language:English
Subjects:
Administration, Topical
Adrenergic Agents - pharmacology
Adult
Aged
Aged, 80 and over
Animals
Biological and medical sciences
Cholinergic Agents - pharmacology
Ciliary Body - drug effects
Ciliary Body - metabolism
Dinoprostone - biosynthesis
Echothiophate Iodide - pharmacology
Epinephrine - pharmacology
Eye
Humans
Intraocular Pressure - drug effects
Iris - drug effects
Iris - metabolism
Medical sciences
Middle Aged
Ocular Hypotension - drug therapy
Ocular Hypotension - metabolism
Ophthalmic Solutions
Pharmacology. Drug treatments
Pilocarpine - pharmacology
Rabbits
Radioimmunoassay
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Summary:Increased PGE2 production by the iris and ciliary body regulate intraocular pressure (IOP) in vivo. Various cholinergic and adrenergic compounds are traditionally used as antiglaucoma drugs, and their effect on IOP reduction is antagonised by cyclooxygenase inhibitors, indicating a role for eicosanoids in their hypotensive activity. One of the most potent antiglaucoma drugs, PG2 alpha (Latanoprost), reduces IOP by increasing uveoscleral outflow and also increases PGE2 production by the iris and ciliary body in vivo. We investigated whether cholinergic and adrenergic antiglaucoma drugs induce the production of prostaglandin E2 (PGE2) in vitro by: 1) the iris-ciliary body (ICB) of rabbits and, 2) irises of glaucoma patients. Pilocarpine 2%, epinephrine 1% and echothiophate iodide 0.125% were applied topically to both eyes of Albino rabbits. Control groups were treated with the corresponding vehicles, or untreated completely. Human iris specimens were obtained from nine untreated cataract eyes, and five eyes under antiglaucoma medication undergoing surgery. PGE2 were determined by a radioimmunoassay. PGE2 production by the ICB of treated rabbits in vitro was twice that of vehicle-treated or untreated rabbit eyes (p
ISSN:1120-6721
1724-6016
DOI:10.1177/112067210301300103