Detection of salivary antibodies in cats infected with feline immunodeficiency virus

Cats infected with feline immunodeficiency virus were examined for total immunoglobulin content and antiviral antibodies. Seropositive cats showed an increase in salivary immunoglobulin G levels, which was only partly attributable to the enhanced prevalence of oral inflammatory lesions, compared wit...

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Bibliographic Details
Published in:Journal of Clinical Microbiology 1992-08, Vol.30 (8), p.2038-2041
Main Authors: Poli, A. (University of Pisa, Pisa, Italy), Giannelli, C, Pistello, M, Zaccaro, L, Pieracci, D, Bendinelli, M, Malvaldi, G
Format: Article
Language:English
Subjects:
AIDS/HIV
Animal viral diseases
Animals
Antibodies, Viral - analysis
ANTICORPS
ANTICUERPOS
Biological and medical sciences
Blotting, Western
Cats
CHAT
DIAGNOSTIC
DIAGNOSTICO
Evaluation Studies as Topic
feline immunodeficiency virus
Fluorescent Antibody Technique
GATO
Immunodeficiency Virus, Feline - immunology
Immunoglobulin A - analysis
Immunoglobulin G - analysis
Immunoglobulin M - analysis
Infectious diseases
LENTIVIRINAE
Lentivirus Infections - immunology
LIQUIDE BIOLOGIQUE
LIQUIDOS CORPORALES
Medical sciences
SALIVA
Saliva - immunology
SALIVE
Viral diseases
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Summary:Cats infected with feline immunodeficiency virus were examined for total immunoglobulin content and antiviral antibodies. Seropositive cats showed an increase in salivary immunoglobulin G levels, which was only partly attributable to the enhanced prevalence of oral inflammatory lesions, compared with the levels in seronegative cats. Immunoglobulin G, but not immunoglobulin M, levels in serum were also increased. Salivary antibodies were determined by indirect immunofluorescence and Western blot (immunoblot) analysis. All but 1 of the 16 seropositive cats examined were positive, while all 16 control cats were negative. The presence of oral lesions was not a prerequisite for antibody detection in saliva. It was concluded that salivary antibody might be usefully exploited for diagnostic and epidemiologic purposes
ISSN:0095-1137
1098-660X
DOI:10.1128/JCM.30.8.2038-2041.1992