Atherogenic profile in preeclampsia

• Published in: Archives of gynecology and obstetrics 2003-04, Vol.268 (1), p.45-47
• Main Authors: Var, Ahmet, Kuşcu, N Kemal, Koyuncu, Faik, Uyanik, B Sami, Onur, Ece, Yildirim, Yasemin, Oruç, Semra
• Format: Article
• Language: English
• Subjects: Adult; Apolipoprotein A-I - blood; Apolipoproteins; Apolipoproteins B - blood; Arteriosclerosis - blood; Case-Control Studies; Female; Humans; Lipoprotein(a) - blood; Malondialdehyde - blood; Pre-Eclampsia - blood; Preeclampsia; Pregnancy
• ISSN: 0932-0067; 1432-0711
• DOI: 10.1007/s00404-002-0317-4

Atherosis is accepted to underlie the pathogenesis of preeclampsia, therefore we aimed to determine malonyldialdehyde (MDA) levels as a marker of lipid peroxidation, and lipoprotein(a) (Lp(a)), apolipoprotein A-1 (Apo A-1) and apolipoprotein B (Apo B) levels as a marker of atherogenic profile in preeclamptic and normal pregnant women. Twenty preeclamptic and 20 gestational-age matched normal pregnant patients were enrolled in the study, mean gestational ages for the preeclamptic and the control group were 33.9+/-1.4 and 35.5+/-0.7 weeks, respectively. Blood was withdrawn from the patients soon after diagnosis, and from the controls at their routine prenatal visits. MDA levels was significantly higher in preeclamptic patients (P=0.0003), but no difference was observed in Apo A-1 and Apo B and Lp(a) levels between the 2 groups. We consider that higher MDA was due to oxidative stress seen in preeclampsia, and similar Apo A-1 and Apo B and Lp(a) levels were due to lack of systemic atherosis.