Parallel Renal and Extremity Blood Supply Abnormalities in Nonmodulation: Responses to ACE Inhibition

ABSTRACT—The aim of this work was to ascertain, in nonmodulating essential hypertension, whether the abnormality in the renal blood supply is extended to the extremities and showed a similar response to ACE inhibition and whether these abnormalities could be identified in normotensive offspring of h...

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Published in:Hypertension (Dallas, Tex. 1979) Tex. 1979), 2003-04, Vol.41 (4), p.919-924
Main Authors: Sánchez, Ramiro A, Ramos, Felipe, Giannone, Carlos, Fischer, Patricia, Masnatta, Lucas, Baglivo, Hugo P, Ramírez, Agustín J, Hollenberg, Norman K
Format: Article
Language:English
Subjects:
Adult
Albuminuria - diagnosis
Angiotensin-Converting Enzyme Inhibitors - pharmacology
Arterial hypertension. Arterial hypotension
Biological and medical sciences
Blood and lymphatic vessels
Cardiology. Vascular system
Clinical manifestations. Epidemiology. Investigative techniques. Etiology
Family Health
Female
Forearm - blood supply
Glomerular Filtration Rate
Humans
Hypertension - genetics
Hypertension - physiopathology
Male
Medical sciences
Plethysmography
Ramipril - pharmacology
Regional Blood Flow - drug effects
Renal Circulation - drug effects
Sodium - administration & dosage
Vascular Resistance - drug effects
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container_end_page 924
container_issue 4
container_start_page 919
container_title Hypertension (Dallas, Tex. 1979)
container_volume 41
creator Sánchez, Ramiro A
Ramos, Felipe
Giannone, Carlos
Fischer, Patricia
Masnatta, Lucas
Baglivo, Hugo P
Ramírez, Agustín J
Hollenberg, Norman K
description ABSTRACT—The aim of this work was to ascertain, in nonmodulating essential hypertension, whether the abnormality in the renal blood supply is extended to the extremities and showed a similar response to ACE inhibition and whether these abnormalities could be identified in normotensive offspring of hypertensives, as non-modulation is a familial process with genetic underpinnings. We measured forearm vascular blood flow (FBF) and forearm vascular resistance (FVR) by plethysmography and urinary albumin excretion in 20 normotensive without family story of hypertension (NT25±9 years), 10 modulating offspring of hypertensive parents (MHO25±6 years), 10 nonmodulating offspring of hypertensive parents (NMHO26±5 years), 12 modulating essential hypertensives (MHT34±5 years), and 11 nonmodulating essential hypertensives (NMHT32±4 years). Measurements were repeated in hypertensives after 3-month treatment with ramipril (5 mg daily). Nonmodulating individuals showed lower maximum FBF (NMHT41.96±3.3 mL/100 g per minute and NMHO35.6±9.0 mL/100 g per minute) than modulating subjects (MHT57.5±10.0 mL/100 g per minute and MHO51.8±7.0 mL/100 g per minute;P
doi_str_mv 10.1161/01.HYP.0000062967.90892.5D
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We measured forearm vascular blood flow (FBF) and forearm vascular resistance (FVR) by plethysmography and urinary albumin excretion in 20 normotensive without family story of hypertension (NT25±9 years), 10 modulating offspring of hypertensive parents (MHO25±6 years), 10 nonmodulating offspring of hypertensive parents (NMHO26±5 years), 12 modulating essential hypertensives (MHT34±5 years), and 11 nonmodulating essential hypertensives (NMHT32±4 years). Measurements were repeated in hypertensives after 3-month treatment with ramipril (5 mg daily). Nonmodulating individuals showed lower maximum FBF (NMHT41.96±3.3 mL/100 g per minute and NMHO35.6±9.0 mL/100 g per minute) than modulating subjects (MHT57.5±10.0 mL/100 g per minute and MHO51.8±7.0 mL/100 g per minute;P &lt;0.003). Likewise, all nonmodulating subjects showed higher minimum FVR (NMHT2.5±0.2 AU; NMO2.8±0.5 AU) than modulating individuals (MHT1.9±0.5 AU; MHO, 1.8±0.3AU;P &lt;0.025). Urinary albumin excretion was higher in NMHT and NMHO than MHT, MHO, and NT (P &lt;0.05). Ramipril increased maximum FBF to 53.8±8.0 mL/100 g per minute and reduced minimum FVR to 1.9±0.5 AU in NMHT (P &lt;0.01). Likewise, ramipril increased effective renal plasma flow and reduced renal vascular resistance and urinary albumin excretion only in NMHT (P &lt;0.05). These results have shown an early involvement of the peripheral circulation in association with increased urinary albumin excretion not only in essential hypertensives but also in NMHO. The effectiveness of ramipril in reducing minimum FVR and urinary albumin excretion in NMHT also suggests a common mechanism.</description><identifier>ISSN: 0194-911X</identifier><identifier>EISSN: 1524-4563</identifier><identifier>DOI: 10.1161/01.HYP.0000062967.90892.5D</identifier><identifier>PMID: 12642507</identifier><identifier>CODEN: HPRTDN</identifier><language>eng</language><publisher>Philadelphia, PA: American Heart Association, Inc</publisher><subject>Adult ; Albuminuria - diagnosis ; Angiotensin-Converting Enzyme Inhibitors - pharmacology ; Arterial hypertension. Arterial hypotension ; Biological and medical sciences ; Blood and lymphatic vessels ; Cardiology. Vascular system ; Clinical manifestations. Epidemiology. Investigative techniques. Etiology ; Family Health ; Female ; Forearm - blood supply ; Glomerular Filtration Rate ; Humans ; Hypertension - genetics ; Hypertension - physiopathology ; Male ; Medical sciences ; Plethysmography ; Ramipril - pharmacology ; Regional Blood Flow - drug effects ; Renal Circulation - drug effects ; Sodium - administration &amp; dosage ; Vascular Resistance - drug effects</subject><ispartof>Hypertension (Dallas, Tex. 1979), 2003-04, Vol.41 (4), p.919-924</ispartof><rights>2003 American Heart Association, Inc.</rights><rights>2003 INIST-CNRS</rights><rights>Copyright American Heart Association, Inc. Apr 2003</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c4019-44ed4f07c8677e870f221848c427e87fa5cdbf89e7cf45a2de2ab330aa2ded6d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&amp;idt=14695192$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12642507$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sánchez, Ramiro A</creatorcontrib><creatorcontrib>Ramos, Felipe</creatorcontrib><creatorcontrib>Giannone, Carlos</creatorcontrib><creatorcontrib>Fischer, Patricia</creatorcontrib><creatorcontrib>Masnatta, Lucas</creatorcontrib><creatorcontrib>Baglivo, Hugo P</creatorcontrib><creatorcontrib>Ramírez, Agustín J</creatorcontrib><creatorcontrib>Hollenberg, Norman K</creatorcontrib><title>Parallel Renal and Extremity Blood Supply Abnormalities in Nonmodulation: Responses to ACE Inhibition</title><title>Hypertension (Dallas, Tex. 1979)</title><addtitle>Hypertension</addtitle><description>ABSTRACT—The aim of this work was to ascertain, in nonmodulating essential hypertension, whether the abnormality in the renal blood supply is extended to the extremities and showed a similar response to ACE inhibition and whether these abnormalities could be identified in normotensive offspring of hypertensives, as non-modulation is a familial process with genetic underpinnings. We measured forearm vascular blood flow (FBF) and forearm vascular resistance (FVR) by plethysmography and urinary albumin excretion in 20 normotensive without family story of hypertension (NT25±9 years), 10 modulating offspring of hypertensive parents (MHO25±6 years), 10 nonmodulating offspring of hypertensive parents (NMHO26±5 years), 12 modulating essential hypertensives (MHT34±5 years), and 11 nonmodulating essential hypertensives (NMHT32±4 years). Measurements were repeated in hypertensives after 3-month treatment with ramipril (5 mg daily). Nonmodulating individuals showed lower maximum FBF (NMHT41.96±3.3 mL/100 g per minute and NMHO35.6±9.0 mL/100 g per minute) than modulating subjects (MHT57.5±10.0 mL/100 g per minute and MHO51.8±7.0 mL/100 g per minute;P &lt;0.003). Likewise, all nonmodulating subjects showed higher minimum FVR (NMHT2.5±0.2 AU; NMO2.8±0.5 AU) than modulating individuals (MHT1.9±0.5 AU; MHO, 1.8±0.3AU;P &lt;0.025). Urinary albumin excretion was higher in NMHT and NMHO than MHT, MHO, and NT (P &lt;0.05). Ramipril increased maximum FBF to 53.8±8.0 mL/100 g per minute and reduced minimum FVR to 1.9±0.5 AU in NMHT (P &lt;0.01). Likewise, ramipril increased effective renal plasma flow and reduced renal vascular resistance and urinary albumin excretion only in NMHT (P &lt;0.05). These results have shown an early involvement of the peripheral circulation in association with increased urinary albumin excretion not only in essential hypertensives but also in NMHO. The effectiveness of ramipril in reducing minimum FVR and urinary albumin excretion in NMHT also suggests a common mechanism.</description><subject>Adult</subject><subject>Albuminuria - diagnosis</subject><subject>Angiotensin-Converting Enzyme Inhibitors - pharmacology</subject><subject>Arterial hypertension. Arterial hypotension</subject><subject>Biological and medical sciences</subject><subject>Blood and lymphatic vessels</subject><subject>Cardiology. Vascular system</subject><subject>Clinical manifestations. Epidemiology. Investigative techniques. Etiology</subject><subject>Family Health</subject><subject>Female</subject><subject>Forearm - blood supply</subject><subject>Glomerular Filtration Rate</subject><subject>Humans</subject><subject>Hypertension - genetics</subject><subject>Hypertension - physiopathology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Plethysmography</subject><subject>Ramipril - pharmacology</subject><subject>Regional Blood Flow - drug effects</subject><subject>Renal Circulation - drug effects</subject><subject>Sodium - administration &amp; dosage</subject><subject>Vascular Resistance - drug effects</subject><issn>0194-911X</issn><issn>1524-4563</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><recordid>eNpdkdtu1DAQhi0EokvhFZBVCe4SbGfsJL3bbhdaqYKKgwRXlpM4WhfHDnaism-P011pJXwznplvDpofoQtKckoF_UBofvPrPifLE6wWZV6TqmY5v36GVpQzyICL4jlaEVpDVlP68wy9ivGBEAoA5Ut0RpkAxkm5QvpeBWWttvirdspi5Tq8_TsFPZhpj6-s9x3-No-j3eN143wYlDWT0REbhz97N_hutmoy3l2mBnH0Lqbc5PF6s8W3bmcasyRfoxe9slG_Odpz9OPj9vvmJrv78ul2s77LWki7ZgC6g56UbSXKUlcl6RmjFVQtsMXtFW-7pq9qXbY9cMU6zVRTFEQt3050xTl6f-g7Bv9n1nGSg4mttlY57ecoy4IKzilN4MV_4IOfQzpAlIxwVlHBIEGXB6gNPsagezkGM6iwl5TIRQlJqExKyJMS8kkJya9T8dvjhLkZdHcqPZ4-Ae-OgIqtsn1QrjXxxIGoOa1Z4uDAPXo76RB_2_lRB7nTyk67p9HARJUxQgoCycuWUF38A57aobs</recordid><startdate>200304</startdate><enddate>200304</enddate><creator>Sánchez, Ramiro A</creator><creator>Ramos, Felipe</creator><creator>Giannone, Carlos</creator><creator>Fischer, Patricia</creator><creator>Masnatta, Lucas</creator><creator>Baglivo, Hugo P</creator><creator>Ramírez, Agustín J</creator><creator>Hollenberg, Norman K</creator><general>American Heart Association, Inc</general><general>Lippincott</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>200304</creationdate><title>Parallel Renal and Extremity Blood Supply Abnormalities in Nonmodulation: Responses to ACE Inhibition</title><author>Sánchez, Ramiro A ; Ramos, Felipe ; Giannone, Carlos ; Fischer, Patricia ; Masnatta, Lucas ; Baglivo, Hugo P ; Ramírez, Agustín J ; Hollenberg, Norman K</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4019-44ed4f07c8677e870f221848c427e87fa5cdbf89e7cf45a2de2ab330aa2ded6d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Adult</topic><topic>Albuminuria - diagnosis</topic><topic>Angiotensin-Converting Enzyme Inhibitors - pharmacology</topic><topic>Arterial hypertension. Arterial hypotension</topic><topic>Biological and medical sciences</topic><topic>Blood and lymphatic vessels</topic><topic>Cardiology. Vascular system</topic><topic>Clinical manifestations. Epidemiology. Investigative techniques. Etiology</topic><topic>Family Health</topic><topic>Female</topic><topic>Forearm - blood supply</topic><topic>Glomerular Filtration Rate</topic><topic>Humans</topic><topic>Hypertension - genetics</topic><topic>Hypertension - physiopathology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Plethysmography</topic><topic>Ramipril - pharmacology</topic><topic>Regional Blood Flow - drug effects</topic><topic>Renal Circulation - drug effects</topic><topic>Sodium - administration &amp; dosage</topic><topic>Vascular Resistance - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sánchez, Ramiro A</creatorcontrib><creatorcontrib>Ramos, Felipe</creatorcontrib><creatorcontrib>Giannone, Carlos</creatorcontrib><creatorcontrib>Fischer, Patricia</creatorcontrib><creatorcontrib>Masnatta, Lucas</creatorcontrib><creatorcontrib>Baglivo, Hugo P</creatorcontrib><creatorcontrib>Ramírez, Agustín J</creatorcontrib><creatorcontrib>Hollenberg, Norman K</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Hypertension (Dallas, Tex. 1979)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sánchez, Ramiro A</au><au>Ramos, Felipe</au><au>Giannone, Carlos</au><au>Fischer, Patricia</au><au>Masnatta, Lucas</au><au>Baglivo, Hugo P</au><au>Ramírez, Agustín J</au><au>Hollenberg, Norman K</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Parallel Renal and Extremity Blood Supply Abnormalities in Nonmodulation: Responses to ACE Inhibition</atitle><jtitle>Hypertension (Dallas, Tex. 1979)</jtitle><addtitle>Hypertension</addtitle><date>2003-04</date><risdate>2003</risdate><volume>41</volume><issue>4</issue><spage>919</spage><epage>924</epage><pages>919-924</pages><issn>0194-911X</issn><eissn>1524-4563</eissn><coden>HPRTDN</coden><abstract>ABSTRACT—The aim of this work was to ascertain, in nonmodulating essential hypertension, whether the abnormality in the renal blood supply is extended to the extremities and showed a similar response to ACE inhibition and whether these abnormalities could be identified in normotensive offspring of hypertensives, as non-modulation is a familial process with genetic underpinnings. We measured forearm vascular blood flow (FBF) and forearm vascular resistance (FVR) by plethysmography and urinary albumin excretion in 20 normotensive without family story of hypertension (NT25±9 years), 10 modulating offspring of hypertensive parents (MHO25±6 years), 10 nonmodulating offspring of hypertensive parents (NMHO26±5 years), 12 modulating essential hypertensives (MHT34±5 years), and 11 nonmodulating essential hypertensives (NMHT32±4 years). Measurements were repeated in hypertensives after 3-month treatment with ramipril (5 mg daily). Nonmodulating individuals showed lower maximum FBF (NMHT41.96±3.3 mL/100 g per minute and NMHO35.6±9.0 mL/100 g per minute) than modulating subjects (MHT57.5±10.0 mL/100 g per minute and MHO51.8±7.0 mL/100 g per minute;P &lt;0.003). Likewise, all nonmodulating subjects showed higher minimum FVR (NMHT2.5±0.2 AU; NMO2.8±0.5 AU) than modulating individuals (MHT1.9±0.5 AU; MHO, 1.8±0.3AU;P &lt;0.025). Urinary albumin excretion was higher in NMHT and NMHO than MHT, MHO, and NT (P &lt;0.05). Ramipril increased maximum FBF to 53.8±8.0 mL/100 g per minute and reduced minimum FVR to 1.9±0.5 AU in NMHT (P &lt;0.01). Likewise, ramipril increased effective renal plasma flow and reduced renal vascular resistance and urinary albumin excretion only in NMHT (P &lt;0.05). These results have shown an early involvement of the peripheral circulation in association with increased urinary albumin excretion not only in essential hypertensives but also in NMHO. The effectiveness of ramipril in reducing minimum FVR and urinary albumin excretion in NMHT also suggests a common mechanism.</abstract><cop>Philadelphia, PA</cop><cop>Hagerstown, MD</cop><pub>American Heart Association, Inc</pub><pmid>12642507</pmid><doi>10.1161/01.HYP.0000062967.90892.5D</doi><tpages>6</tpages></addata></record>
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identifier ISSN: 0194-911X
ispartof Hypertension (Dallas, Tex. 1979), 2003-04, Vol.41 (4), p.919-924
issn 0194-911X
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source EZB Electronic Journals Library
subjects Adult
Albuminuria - diagnosis
Angiotensin-Converting Enzyme Inhibitors - pharmacology
Arterial hypertension. Arterial hypotension
Biological and medical sciences
Blood and lymphatic vessels
Cardiology. Vascular system
Clinical manifestations. Epidemiology. Investigative techniques. Etiology
Family Health
Female
Forearm - blood supply
Glomerular Filtration Rate
Humans
Hypertension - genetics
Hypertension - physiopathology
Male
Medical sciences
Plethysmography
Ramipril - pharmacology
Regional Blood Flow - drug effects
Renal Circulation - drug effects
Sodium - administration & dosage
Vascular Resistance - drug effects
title Parallel Renal and Extremity Blood Supply Abnormalities in Nonmodulation: Responses to ACE Inhibition
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