Extensive Retinal Neovascularization as a Late Finding in Human Immunodeficiency Virus-Infected Patients with Immune Recovery Uveitis

Sixteen human immunodeficiency virus (HIV)-infected patients with inactive cytomegalovirus (CMV) retinitis who had discontinued systemic anti-CMV therapy while receiving highly active antiretroviral therapy (HAART) were prospectively observed. Fifteen patients developed immune recovery uveitis (IRU)...

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Bibliographic Details
Published in:Clinical infectious diseases 2003-04, Vol.36 (8), p.1063-1066
Main Authors: Wright, Mary E., Suzman, Daniel L., Csaky, Karl G., Masur, Henry, Polis, Michael A., Robinson, Michael R.
Format: Article
Language:English
Subjects:
Adult
AIDS
Angiogenesis
Antiretroviral Therapy, Highly Active
Biological and medical sciences
CD4 Lymphocyte Count
Cytomegalovirus
Cytomegalovirus retinitis
Highly active antiretroviral therapy
HIV infections
HIV Infections - complications
HIV Infections - drug therapy
HIV Infections - immunology
HIV/AIDS
Human viral diseases
Humans
Infectious diseases
Male
Medical sciences
Middle Aged
Ophthalmology
Retina
Retinal neovascularization
Retinal Neovascularization - etiology
Retinal Neovascularization - immunology
Retinitis
Retinopathies
Uveitis
Uveitis - complications
Uveitis - immunology
Viral diseases
Viral diseases of the lymphoid tissue and the blood. Aids
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Summary:Sixteen human immunodeficiency virus (HIV)-infected patients with inactive cytomegalovirus (CMV) retinitis who had discontinued systemic anti-CMV therapy while receiving highly active antiretroviral therapy (HAART) were prospectively observed. Fifteen patients developed immune recovery uveitis (IRU); 3 of the patients developed extensive retinal neovascularization, 1 of whom required vitrectomy for recurrent vitreous hemorrhages. These late complications indicate a need for continued ophthalmologic follow-up of HIV-infected patients who have a history of CMV retinitis, even for individuals who have not required anti-CMV therapy for >4 years.
ISSN:1058-4838
1537-6591
DOI:10.1086/374050