Use of Magnetic Resonance Imaging to Analyze the Performance of Hollow-Fiber Bioreactors

Preliminary experiments were described that demonstrate that MRI is an effective tool for the noninvasive study of hollow-fiber bioreactors. Flow-compensated velocity-encoding pulse sequences were successively applied to analyze the velocity patterns in a module operated without cells, with an artif...

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Bibliographic Details
Published in:Annals of the New York Academy of Sciences 1992-10, Vol.665 (1), p.285-300
Main Authors: DONOGHUE, C., BRIDEAU, M., NEWCOMER, P., PANGRLE, B., DiBIASIO, D., WALSH, E., MOORE, S.
Format: Article
Language:English
Subjects:
Animals
Biotechnology - instrumentation
Biotechnology - methods
Cell Division
Cells, Cultured
Culture Techniques - instrumentation
Culture Techniques - methods
Diffusion
Magnetic Resonance Imaging - methods
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Summary:Preliminary experiments were described that demonstrate that MRI is an effective tool for the noninvasive study of hollow-fiber bioreactors. Flow-compensated velocity-encoding pulse sequences were successively applied to analyze the velocity patterns in a module operated without cells, with an artificially induced flow field perturbation. Diffusion damping pulse sequences were also used to spatially resolve regions of cell growth in a bioreactor. These experiments provide the necessary basis from which future flow and spectroscopic studies can be conducted.
ISSN:0077-8923
1749-6632
DOI:10.1111/j.1749-6632.1992.tb42592.x