Loading…
Characterization of wheezing phenotypes in the first 10 years of life
Summary Background Childhood wheezing illnesses are characterized into different phenotypes. However, severity of the disease associated with these phenotypes has not been extensively studied. Objectives To determine characteristics of childhood wheezing phenotypes in the first decade of life using...
Saved in:
| Published in: | Clinical and experimental allergy 2003-05, Vol.33 (5), p.573-578 |
|---|---|
| Main Authors: | , , , , , |
| Format: | Article |
| Language: | English |
| Subjects: | |
| Citations: | Items that this one cites Items that cite this one |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| cited_by | cdi_FETCH-LOGICAL-c5577-69e577bb8f87c29a9e37f0f0e15d0e468a0d59d4e57ae3cd90a0b3b9d07e9cd43 |
|---|---|
| cites | cdi_FETCH-LOGICAL-c5577-69e577bb8f87c29a9e37f0f0e15d0e468a0d59d4e57ae3cd90a0b3b9d07e9cd43 |
| container_end_page | 578 |
| container_issue | 5 |
| container_start_page | 573 |
| container_title | Clinical and experimental allergy |
| container_volume | 33 |
| creator | Kurukulaaratchy, R. J. Fenn, M. H. Waterhouse, L. M. Matthews, S. M. Holgate, S. T. Arshad, S. H. |
| description | Summary
Background Childhood wheezing illnesses are characterized into different phenotypes. However, severity of the disease associated with these phenotypes has not been extensively studied.
Objectives To determine characteristics of childhood wheezing phenotypes in the first decade of life using health outcomes plus measurements of atopy, lung function and bronchial hyper‐responsiveness.
Methods A whole population birth cohort (n = 1456) was prospectively studied to examine the natural history of childhood wheezing. Children were seen at 1, 2, 4 and 10 years for questionnaire completion and prospectively collected data used to define wheezing phenotypes. Assessment was made of adverse health outcomes plus spirometry, bronchial hyper‐responsiveness, serum IgE measurement at 10 years and skin test sensitization at both 4 and 10 years for wheezing phenotypes.
Results Phenotypic analysis identified that 37% early life wheezers (symptom onset by age 4 years) still wheezed at 10 years. These persistent wheezers showed significantly more physician‐diagnosed asthma in early life (P |
| doi_str_mv | 10.1046/j.1365-2222.2003.01657.x |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_73278254</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>350624621</sourcerecordid><originalsourceid>FETCH-LOGICAL-c5577-69e577bb8f87c29a9e37f0f0e15d0e468a0d59d4e57ae3cd90a0b3b9d07e9cd43</originalsourceid><addsrcrecordid>eNqNkU9v1DAQxS0EokvhK6AICW5Jx_9i-8ChLEup1JYeQBwtJ5mwXrLJYmfV3X56HHbVSlxgLjOSf280fo-QjEJBQZRnq4LyUuYsVcEAeAG0lKrYPSGzh4enZAZGilxpI07IixhXkEhp9HNyQpmSTGoxI4v50gVXjxj8vRv90GdDm90tEe99_yPbLLEfxv0GY-b7bFxi1voQx3RHtkcX4gR3vsWX5Fnruoivjv2UfPu0-Dr_nF99ubicn1_ltZRK5aXB1KpKt1rVzDiDXLXQAlLZAIpSO2ikaUSiHPK6MeCg4pVpQKGpG8FPybvD3k0Yfm0xjnbtY41d53octtEqzpRm8t8gTaYwYCaBb_4CV8M29OkTlhpjgAktE6QPUB2GGAO2dhP82oW9pWCnQOzKTr7byXc7BWL_BGJ3Sfr6uH9brbF5FB4TSMDbI-Bi7bo2uL728ZETimstaOLeH7g73-H-vw-w88X5NCV9ftD7OOLuQe_CT1sqrqT9fnNh2cdb-HAN0t7y35cbs80</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>199902485</pqid></control><display><type>article</type><title>Characterization of wheezing phenotypes in the first 10 years of life</title><source>Wiley</source><creator>Kurukulaaratchy, R. J. ; Fenn, M. H. ; Waterhouse, L. M. ; Matthews, S. M. ; Holgate, S. T. ; Arshad, S. H.</creator><creatorcontrib>Kurukulaaratchy, R. J. ; Fenn, M. H. ; Waterhouse, L. M. ; Matthews, S. M. ; Holgate, S. T. ; Arshad, S. H.</creatorcontrib><description><![CDATA[Summary
Background Childhood wheezing illnesses are characterized into different phenotypes. However, severity of the disease associated with these phenotypes has not been extensively studied.
Objectives To determine characteristics of childhood wheezing phenotypes in the first decade of life using health outcomes plus measurements of atopy, lung function and bronchial hyper‐responsiveness.
Methods A whole population birth cohort (n = 1456) was prospectively studied to examine the natural history of childhood wheezing. Children were seen at 1, 2, 4 and 10 years for questionnaire completion and prospectively collected data used to define wheezing phenotypes. Assessment was made of adverse health outcomes plus spirometry, bronchial hyper‐responsiveness, serum IgE measurement at 10 years and skin test sensitization at both 4 and 10 years for wheezing phenotypes.
Results Phenotypic analysis identified that 37% early life wheezers (symptom onset by age 4 years) still wheezed at 10 years. These persistent wheezers showed significantly more physician‐diagnosed asthma in early life (P < 0.005 at 2 years) than early transient wheezers (wheezing transiently with onset by age 4 years). Overall they experienced greater multiple hospital admissions (P = 0.024), specialist referral (P = 0.009) and use of inhaled (P < 0.001) and oral steroids (P < 0.001) than early transient wheezers. They also demonstrated enhanced bronchial hyper‐responsiveness compared with early transient wheezers (P < 0.001). However, both groups of early life wheezers showed impairment of baseline lung function at 10 years in comparison with non‐wheezers: FEV1 (P < 0.029) and FEV1/FVC ratio (P < 0.001) with persistent wheeze and PEF (P = 0.036) with early transient wheeze. Late‐onset wheezers (onset from 5 years onwards) had similar BHR to persistent wheezers but maintained normal lung function at age 10 and had lower cumulative prevalence of adverse health outcomes than persistent wheezers.
Conclusions Persistent wheezing with early childhood onset is associated with substantial morbidity in the first decade of life in association with high levels of atopy, bronchial hyper‐responsiveness and impaired lung function at 10 years of age. Late‐onset wheezing in the first decade of life could harbour potential for similarly significant disease subsequently.]]></description><identifier>ISSN: 0954-7894</identifier><identifier>EISSN: 1365-2222</identifier><identifier>DOI: 10.1046/j.1365-2222.2003.01657.x</identifier><identifier>PMID: 12752584</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Science Ltd</publisher><subject>Age of Onset ; Allergic diseases ; atopy ; Biological and medical sciences ; bronchial hyper-responsiveness ; Bronchial Hyperreactivity - blood ; Bronchial Hyperreactivity - epidemiology ; Bronchial Hyperreactivity - genetics ; childhood asthma ; England - epidemiology ; Female ; Follow-Up Studies ; Glucocorticoids - administration & dosage ; Health Resources - statistics & numerical data ; Hospitalization - statistics & numerical data ; Humans ; Hypersensitivity - epidemiology ; Immunopathology ; Infant, Newborn ; Male ; Medical sciences ; Morbidity ; Phenotype ; Prognosis ; Prospective Studies ; Referral and Consultation - statistics & numerical data ; Respiratory and ent allergic diseases ; Respiratory Mechanics ; Respiratory Sounds - diagnosis ; Respiratory Sounds - physiopathology ; wheezing phenotypes</subject><ispartof>Clinical and experimental allergy, 2003-05, Vol.33 (5), p.573-578</ispartof><rights>2003 INIST-CNRS</rights><rights>Copyright Blackwell Scientific Publications Ltd. May 2003</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5577-69e577bb8f87c29a9e37f0f0e15d0e468a0d59d4e57ae3cd90a0b3b9d07e9cd43</citedby><cites>FETCH-LOGICAL-c5577-69e577bb8f87c29a9e37f0f0e15d0e468a0d59d4e57ae3cd90a0b3b9d07e9cd43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14738841$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12752584$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kurukulaaratchy, R. J.</creatorcontrib><creatorcontrib>Fenn, M. H.</creatorcontrib><creatorcontrib>Waterhouse, L. M.</creatorcontrib><creatorcontrib>Matthews, S. M.</creatorcontrib><creatorcontrib>Holgate, S. T.</creatorcontrib><creatorcontrib>Arshad, S. H.</creatorcontrib><title>Characterization of wheezing phenotypes in the first 10 years of life</title><title>Clinical and experimental allergy</title><addtitle>Clin Exp Allergy</addtitle><description><![CDATA[Summary
Background Childhood wheezing illnesses are characterized into different phenotypes. However, severity of the disease associated with these phenotypes has not been extensively studied.
Objectives To determine characteristics of childhood wheezing phenotypes in the first decade of life using health outcomes plus measurements of atopy, lung function and bronchial hyper‐responsiveness.
Methods A whole population birth cohort (n = 1456) was prospectively studied to examine the natural history of childhood wheezing. Children were seen at 1, 2, 4 and 10 years for questionnaire completion and prospectively collected data used to define wheezing phenotypes. Assessment was made of adverse health outcomes plus spirometry, bronchial hyper‐responsiveness, serum IgE measurement at 10 years and skin test sensitization at both 4 and 10 years for wheezing phenotypes.
Results Phenotypic analysis identified that 37% early life wheezers (symptom onset by age 4 years) still wheezed at 10 years. These persistent wheezers showed significantly more physician‐diagnosed asthma in early life (P < 0.005 at 2 years) than early transient wheezers (wheezing transiently with onset by age 4 years). Overall they experienced greater multiple hospital admissions (P = 0.024), specialist referral (P = 0.009) and use of inhaled (P < 0.001) and oral steroids (P < 0.001) than early transient wheezers. They also demonstrated enhanced bronchial hyper‐responsiveness compared with early transient wheezers (P < 0.001). However, both groups of early life wheezers showed impairment of baseline lung function at 10 years in comparison with non‐wheezers: FEV1 (P < 0.029) and FEV1/FVC ratio (P < 0.001) with persistent wheeze and PEF (P = 0.036) with early transient wheeze. Late‐onset wheezers (onset from 5 years onwards) had similar BHR to persistent wheezers but maintained normal lung function at age 10 and had lower cumulative prevalence of adverse health outcomes than persistent wheezers.
Conclusions Persistent wheezing with early childhood onset is associated with substantial morbidity in the first decade of life in association with high levels of atopy, bronchial hyper‐responsiveness and impaired lung function at 10 years of age. Late‐onset wheezing in the first decade of life could harbour potential for similarly significant disease subsequently.]]></description><subject>Age of Onset</subject><subject>Allergic diseases</subject><subject>atopy</subject><subject>Biological and medical sciences</subject><subject>bronchial hyper-responsiveness</subject><subject>Bronchial Hyperreactivity - blood</subject><subject>Bronchial Hyperreactivity - epidemiology</subject><subject>Bronchial Hyperreactivity - genetics</subject><subject>childhood asthma</subject><subject>England - epidemiology</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Glucocorticoids - administration & dosage</subject><subject>Health Resources - statistics & numerical data</subject><subject>Hospitalization - statistics & numerical data</subject><subject>Humans</subject><subject>Hypersensitivity - epidemiology</subject><subject>Immunopathology</subject><subject>Infant, Newborn</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Morbidity</subject><subject>Phenotype</subject><subject>Prognosis</subject><subject>Prospective Studies</subject><subject>Referral and Consultation - statistics & numerical data</subject><subject>Respiratory and ent allergic diseases</subject><subject>Respiratory Mechanics</subject><subject>Respiratory Sounds - diagnosis</subject><subject>Respiratory Sounds - physiopathology</subject><subject>wheezing phenotypes</subject><issn>0954-7894</issn><issn>1365-2222</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><recordid>eNqNkU9v1DAQxS0EokvhK6AICW5Jx_9i-8ChLEup1JYeQBwtJ5mwXrLJYmfV3X56HHbVSlxgLjOSf280fo-QjEJBQZRnq4LyUuYsVcEAeAG0lKrYPSGzh4enZAZGilxpI07IixhXkEhp9HNyQpmSTGoxI4v50gVXjxj8vRv90GdDm90tEe99_yPbLLEfxv0GY-b7bFxi1voQx3RHtkcX4gR3vsWX5Fnruoivjv2UfPu0-Dr_nF99ubicn1_ltZRK5aXB1KpKt1rVzDiDXLXQAlLZAIpSO2ikaUSiHPK6MeCg4pVpQKGpG8FPybvD3k0Yfm0xjnbtY41d53octtEqzpRm8t8gTaYwYCaBb_4CV8M29OkTlhpjgAktE6QPUB2GGAO2dhP82oW9pWCnQOzKTr7byXc7BWL_BGJ3Sfr6uH9brbF5FB4TSMDbI-Bi7bo2uL728ZETimstaOLeH7g73-H-vw-w88X5NCV9ftD7OOLuQe_CT1sqrqT9fnNh2cdb-HAN0t7y35cbs80</recordid><startdate>200305</startdate><enddate>200305</enddate><creator>Kurukulaaratchy, R. J.</creator><creator>Fenn, M. H.</creator><creator>Waterhouse, L. M.</creator><creator>Matthews, S. M.</creator><creator>Holgate, S. T.</creator><creator>Arshad, S. H.</creator><general>Blackwell Science Ltd</general><general>Blackwell</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>200305</creationdate><title>Characterization of wheezing phenotypes in the first 10 years of life</title><author>Kurukulaaratchy, R. J. ; Fenn, M. H. ; Waterhouse, L. M. ; Matthews, S. M. ; Holgate, S. T. ; Arshad, S. H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5577-69e577bb8f87c29a9e37f0f0e15d0e468a0d59d4e57ae3cd90a0b3b9d07e9cd43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Age of Onset</topic><topic>Allergic diseases</topic><topic>atopy</topic><topic>Biological and medical sciences</topic><topic>bronchial hyper-responsiveness</topic><topic>Bronchial Hyperreactivity - blood</topic><topic>Bronchial Hyperreactivity - epidemiology</topic><topic>Bronchial Hyperreactivity - genetics</topic><topic>childhood asthma</topic><topic>England - epidemiology</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Glucocorticoids - administration & dosage</topic><topic>Health Resources - statistics & numerical data</topic><topic>Hospitalization - statistics & numerical data</topic><topic>Humans</topic><topic>Hypersensitivity - epidemiology</topic><topic>Immunopathology</topic><topic>Infant, Newborn</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Morbidity</topic><topic>Phenotype</topic><topic>Prognosis</topic><topic>Prospective Studies</topic><topic>Referral and Consultation - statistics & numerical data</topic><topic>Respiratory and ent allergic diseases</topic><topic>Respiratory Mechanics</topic><topic>Respiratory Sounds - diagnosis</topic><topic>Respiratory Sounds - physiopathology</topic><topic>wheezing phenotypes</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kurukulaaratchy, R. J.</creatorcontrib><creatorcontrib>Fenn, M. H.</creatorcontrib><creatorcontrib>Waterhouse, L. M.</creatorcontrib><creatorcontrib>Matthews, S. M.</creatorcontrib><creatorcontrib>Holgate, S. T.</creatorcontrib><creatorcontrib>Arshad, S. H.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical and experimental allergy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kurukulaaratchy, R. J.</au><au>Fenn, M. H.</au><au>Waterhouse, L. M.</au><au>Matthews, S. M.</au><au>Holgate, S. T.</au><au>Arshad, S. H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Characterization of wheezing phenotypes in the first 10 years of life</atitle><jtitle>Clinical and experimental allergy</jtitle><addtitle>Clin Exp Allergy</addtitle><date>2003-05</date><risdate>2003</risdate><volume>33</volume><issue>5</issue><spage>573</spage><epage>578</epage><pages>573-578</pages><issn>0954-7894</issn><eissn>1365-2222</eissn><abstract><![CDATA[Summary
Background Childhood wheezing illnesses are characterized into different phenotypes. However, severity of the disease associated with these phenotypes has not been extensively studied.
Objectives To determine characteristics of childhood wheezing phenotypes in the first decade of life using health outcomes plus measurements of atopy, lung function and bronchial hyper‐responsiveness.
Methods A whole population birth cohort (n = 1456) was prospectively studied to examine the natural history of childhood wheezing. Children were seen at 1, 2, 4 and 10 years for questionnaire completion and prospectively collected data used to define wheezing phenotypes. Assessment was made of adverse health outcomes plus spirometry, bronchial hyper‐responsiveness, serum IgE measurement at 10 years and skin test sensitization at both 4 and 10 years for wheezing phenotypes.
Results Phenotypic analysis identified that 37% early life wheezers (symptom onset by age 4 years) still wheezed at 10 years. These persistent wheezers showed significantly more physician‐diagnosed asthma in early life (P < 0.005 at 2 years) than early transient wheezers (wheezing transiently with onset by age 4 years). Overall they experienced greater multiple hospital admissions (P = 0.024), specialist referral (P = 0.009) and use of inhaled (P < 0.001) and oral steroids (P < 0.001) than early transient wheezers. They also demonstrated enhanced bronchial hyper‐responsiveness compared with early transient wheezers (P < 0.001). However, both groups of early life wheezers showed impairment of baseline lung function at 10 years in comparison with non‐wheezers: FEV1 (P < 0.029) and FEV1/FVC ratio (P < 0.001) with persistent wheeze and PEF (P = 0.036) with early transient wheeze. Late‐onset wheezers (onset from 5 years onwards) had similar BHR to persistent wheezers but maintained normal lung function at age 10 and had lower cumulative prevalence of adverse health outcomes than persistent wheezers.
Conclusions Persistent wheezing with early childhood onset is associated with substantial morbidity in the first decade of life in association with high levels of atopy, bronchial hyper‐responsiveness and impaired lung function at 10 years of age. Late‐onset wheezing in the first decade of life could harbour potential for similarly significant disease subsequently.]]></abstract><cop>Oxford, UK</cop><pub>Blackwell Science Ltd</pub><pmid>12752584</pmid><doi>10.1046/j.1365-2222.2003.01657.x</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0954-7894 |
| ispartof | Clinical and experimental allergy, 2003-05, Vol.33 (5), p.573-578 |
| issn | 0954-7894 1365-2222 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_73278254 |
| source | Wiley |
| subjects | Age of Onset Allergic diseases atopy Biological and medical sciences bronchial hyper-responsiveness Bronchial Hyperreactivity - blood Bronchial Hyperreactivity - epidemiology Bronchial Hyperreactivity - genetics childhood asthma England - epidemiology Female Follow-Up Studies Glucocorticoids - administration & dosage Health Resources - statistics & numerical data Hospitalization - statistics & numerical data Humans Hypersensitivity - epidemiology Immunopathology Infant, Newborn Male Medical sciences Morbidity Phenotype Prognosis Prospective Studies Referral and Consultation - statistics & numerical data Respiratory and ent allergic diseases Respiratory Mechanics Respiratory Sounds - diagnosis Respiratory Sounds - physiopathology wheezing phenotypes |
| title | Characterization of wheezing phenotypes in the first 10 years of life |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-29T11%3A37%3A53IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Characterization%20of%20wheezing%20phenotypes%20in%20the%20first%2010%20years%20of%20life&rft.jtitle=Clinical%20and%20experimental%20allergy&rft.au=Kurukulaaratchy,%20R.%20J.&rft.date=2003-05&rft.volume=33&rft.issue=5&rft.spage=573&rft.epage=578&rft.pages=573-578&rft.issn=0954-7894&rft.eissn=1365-2222&rft_id=info:doi/10.1046/j.1365-2222.2003.01657.x&rft_dat=%3Cproquest_cross%3E350624621%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c5577-69e577bb8f87c29a9e37f0f0e15d0e468a0d59d4e57ae3cd90a0b3b9d07e9cd43%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=199902485&rft_id=info:pmid/12752584&rfr_iscdi=true |