Nitric oxide does not mediate flow induced endothelium dependent arterial dilatation in the cat

Objective: The aim was to determine whether the endothelium derived nitric oxide formed from L-arginine is the factor which mediates flow induced dilatation of conduit arteries. Methods: Changes in diameter of feline femoral artery caused by blood flow rate increases, acetylcholine, and ATP were rec...

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Published in:Cardiovascular research 1992-03, Vol.26 (3), p.256-260
Main Authors: Melkumyants, Arthur M, Balashov, Sergey A, Klimachev, Alexandr N, Kartamyshev, Sergey P, Khayutin, Vladimir M
Format: Article
Language:English
Subjects:
acetylcholine
Acetylcholine - pharmacology
Animals
Arginine - analogs & derivatives
Arginine - pharmacology
ATP
blood flow rate
Blood Pressure - drug effects
Cats
EDRF (endothelium derived relaxing factor)
Endothelium, Vascular - metabolism
Female
Femoral Artery - drug effects
Femoral Artery - physiology
L-arginine
Male
NG-nitro-L-arginine
NG-Nitroarginine Methyl Ester
nitric oxide
Nitric Oxide - metabolism
omega-N-Methylarginine
Regional Blood Flow - physiology
shear stress
vasodilatation
Vasodilation - drug effects
Vasodilation - physiology
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Summary:Objective: The aim was to determine whether the endothelium derived nitric oxide formed from L-arginine is the factor which mediates flow induced dilatation of conduit arteries. Methods: Changes in diameter of feline femoral artery caused by blood flow rate increases, acetylcholine, and ATP were recorded during perfusion with blood in situ before and after the inhibition of endothelium derived nitric oxide synthesis by NG-nitro-L-arginine methyl ester and NG-monomethyl-L-arginine. Fourteen anaesthetised cats of either sex, weight 2.6-3.9 kg, were used for the studies. Results: Intravenous administration of NG-nitro-L-arginine methyl ester and NG-monoethyl-L-arginine in doses 10 and 30 mg·kg−1 evoked a rise in mean systemic arterial pressure, constriction of the femoral artery, and considerable decrease in acetylcholine and ATP induced dilatation. However, it did not affect the dilator response induced by increased blood flow rate. Conclusions: Flow induced endothelium dependent arterial dilatation is not mediated by nitric oxide or, if nitric oxide is still released in response to flow rate increase, it has a source distinct from L-arginine.
ISSN:0008-6363
1755-3245
DOI:10.1093/cvr/26.3.256