Blockade of Dopamine Activity in the Nucleus Accumbens Impairs Learning Extinction of Conditioned Fear

Three experiments used rats to investigate the role of dopamine activity in learning to inhibit conditioned fear responses (freezing) in extinction. In Experiment 1, rats systemically injected with the D2 dopamine antagonist, haloperidol, froze more across multiple extinction sessions and on a drug-...

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Bibliographic Details
Published in:Learning & memory (Cold Spring Harbor, N.Y.) N.Y.), 2010-02, Vol.17 (2), p.71-75
Main Authors: Holtzman-Assif, Orit, Laurent, Vincent, Westbrook, R. Frederick
Format: Article
Language:English
Subjects:
Animals
Biochemistry
Brain Hemisphere Functions
Conditioning
Conditioning, Classical - drug effects
Conditioning, Classical - physiology
Control Groups
Dopamine - analysis
Dopamine - physiology
Dopamine Antagonists - pharmacology
Dose-Response Relationship, Drug
Extinction, Psychological - drug effects
Extinction, Psychological - physiology
Fear
Fear - drug effects
Fear - physiology
Freezing Reaction, Cataleptic - drug effects
Freezing Reaction, Cataleptic - physiology
Haloperidol - pharmacology
Inhibition (Psychology)
Injections, Intraventricular
Learning Processes
Male
Nucleus Accumbens - chemistry
Nucleus Accumbens - physiology
Prediction
Rats
Rats, Wistar
Responses
Retention (Psychology)
Role
Tests
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Summary:Three experiments used rats to investigate the role of dopamine activity in learning to inhibit conditioned fear responses (freezing) in extinction. In Experiment 1, rats systemically injected with the D2 dopamine antagonist, haloperidol, froze more across multiple extinction sessions and on a drug-free retention test than control rats. In Experiment 2, rats extinguished under an intracerebroventricular (ICV) infusion of haloperidol suppressed fear responses across extinction but froze more on a subsequent drug-free retention test than control rats. In Experiment 3, rats extinguished under an infusion of haloperidol in the nucleus accumbens were impaired in suppressing fear responses across extinction and froze more on subsequent drug-free retention test than control rats. These results show that learning to inhibit fear responses in extinction requires dopamine activity in the nucleus accumbens. They were interpreted to mean that dopaminergic activity in the nucleus accumbens regulates the prediction error required for learning to inhibit fear responses in extinction.
ISSN:1072-0502
1549-5485
DOI:10.1101/lm.1668310