Fetal cystic lung lesions: Evaluation with magnetic resonance imaging

• Published in: Pediatric pulmonology 2010-06, Vol.45 (6), p.592-600
• Main Authors: Liu, Yu-Peng, Chen, Chih-Ping, Shih, Shin-Lin, Chen, Yi-Fang, Yang, Fei-Shih, Chen, Su-Chiu
• Format: Article
• Language: English
• Subjects: Biological and medical sciences; Blood Vessels - abnormalities; bronchopulmonary sequestration; Bronchopulmonary Sequestration - diagnosis; Chronic obstructive pulmonary disease, asthma; congenital cystic adenomatoid malformation; congenital lobar emphysema; Cystic Adenomatoid Malformation of Lung, Congenital - diagnosis; Female; fetal cystic lung lesions; Fetus - abnormalities; General aspects; Humans; Lung - abnormalities; Lung - blood supply; Magnetic Resonance Imaging; Male; Medical sciences; MRI; Pneumology; Prenatal Diagnosis - methods; Pulmonary Emphysema - diagnosis; Retrospective Studies
• ISSN: 8755-6863; 1099-0496
• DOI: 10.1002/ppul.21226

Objectives To investigate the contribution of magnetic resonance imaging (MRI) to the diagnosis of fetal cystic lung lesions found on routine prenatal ultrasound (US). Study Design Experienced radiologists retrospectively reviewed 34 fetal MRI studies performed in 20 fetuses (from 20 to 35 gestational weeks; including 14 repeat studies 10 weeks after the initial MRI), focusing on shape, signal characteristics, feeding artery, volume change, and location of the cystic lesions. Diagnoses were confirmed after birth by postnatal multidetector computed tomography (MDCT) and/or surgery. Results Bronchopulmonary sequestration (BPS) in the second trimester appeared as a well‐defined, homogeneous, hyperintense mass (pure BPS) in eight cases or as a lobulated, inhomogeneous hyperintense mass (BPS mixed with congenital cystic adenomatoid malformation (CCAM)) in three cases. The feeding artery was visible in all 11 cases in the initial MRI, and regression of the mass was seen in 7 cases. As the mass regressed in the third trimester, the signal intensity decreased, becoming inhomogeneous, and the margins became lobulated. The mean initial ratio of the volume of the BPS lesion to the ipsilateral lung in lesions with partial regression was 82%; the mean initial ratio in lesions with nearly complete regression was 61%. CCAM (6) cases also appeared as a hyperintense lobulated mass, and as the lesions regressed, they decreased in size and signal intensity. As with BPS, the larger the lesion on initial MRI, the less likely it was to regress completely. Congenital lobar fluid overload in three cases appeared as a hyperintense, homogeneous lobe with stretched hilar vessels. Conclusion Prenatal MRI is useful as a diagnostic tool complementary to US for evaluating fetal cystic lung lesions. Smaller lung lesions (