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Biotransformation of α-Cedrol and Caryophyllene Oxide by the Fungus Neurospora crassa

Incubation of α-cedrol and caryophyllene oxide with Neurospora crassa afforded 12β-hydroxy cedrol, 10α-hydroxy cedrol, and 3β-hydroxy cedrol, and 12β-hydroxy caryophyllene oxide as major metabolites, respectively. The antibacterial and radical scavenging activities of the metabolites were evaluated...

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Published in:	Natural product communications 2010-04, Vol.5 (4), p.515-518
Main Authors:	Kiran, Ismail, Durceylan, Zeynep, Kirimer, Neşe, Başer, K. Hüsnü Can, Noma, Yoshiaki, Demirci, Fatih
Format:	Article
Language:	English
Subjects:	Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - metabolism Anti-Bacterial Agents - pharmacology Biotransformation Biphenyl Compounds - chemistry Free Radical Scavengers - chemistry Free Radical Scavengers - metabolism Free Radical Scavengers - pharmacology Microbial Sensitivity Tests Neurospora crassa - metabolism Picrates - chemistry Sesquiterpenes - chemistry Sesquiterpenes - metabolism Sesquiterpenes - pharmacology Terpenes - chemistry Terpenes - metabolism Terpenes - pharmacology
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creator	Kiran, Ismail Durceylan, Zeynep Kirimer, Neşe Başer, K. Hüsnü Can Noma, Yoshiaki Demirci, Fatih
description	Incubation of α-cedrol and caryophyllene oxide with Neurospora crassa afforded 12β-hydroxy cedrol, 10α-hydroxy cedrol, and 3β-hydroxy cedrol, and 12β-hydroxy caryophyllene oxide as major metabolites, respectively. The antibacterial and radical scavenging activities of the metabolites were evaluated in vitro using broth microdilution and bioauthographic techniques. However, no significant antibacterial and antioxidant activities were observed when compared with those of standard substances.
doi_str_mv	10.1177/1934578X1000500403
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title	Biotransformation of α-Cedrol and Caryophyllene Oxide by the Fungus Neurospora crassa
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