Consecutive versus alternating cycles of ovarian stimulation using human menopausal gonadotrophin

Ovarian stimulation is an effective treatment for patients with ovulatory dysfunction and unexplained infertility. An initial report has suggested that consecutive cycles of ovarian stimulation can be employed without causing a diminished response in the second cycle. However, this observation has n...

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Bibliographic Details
Published in:Human reproduction (Oxford) 1992-08, Vol.7 (7), p.940-944
Main Authors: Silverberg, Kaylen M., Klein, Nancy A., Burns, William N., Schenken, Robert S., Olive, David L.
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
Birth control
consecutive cycles
Female
Gynecology. Andrology. Obstetrics
Humans
infertility
Medical sciences
menotrophins
Menotropins - administration & dosage
Ovarian Follicle - drug effects
Ovarian Follicle - physiology
Ovary - drug effects
ovulation induction
Ovulation Induction - methods
Retrospective Studies
Sterility. Assisted procreation
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Summary:Ovarian stimulation is an effective treatment for patients with ovulatory dysfunction and unexplained infertility. An initial report has suggested that consecutive cycles of ovarian stimulation can be employed without causing a diminished response in the second cycle. However, this observation has neither been confirmed nor has a regimen of consecutive stimulation cycles been compared to one of alternating stimulation cycles. Accordingly, 44 consecutive and 54 alternating cycles of stimulation were evaluated in patients (n = 42) who were treated with human menopausal gonado-trophin (HMG) alone. Human chorionic gonadotrophin (HCG) 10 000 IU was administered i.m. when at least one follicle exceeded 16 mm in mean diameter, and this was followed by either intercourse or intrauterine insemination. Using each patient as her own control, we were unable to demonstrate any differences in mean HMG dose requirements, endocrine parameters or follkular development on the day of HCG administration, or ovulation rates in the second consecutive cycle compared to the second alternating cycle. Clinical pregnancies resulted significantly more often in a consecutive cycle (8/22) than in an alternating cycle (2/27, P = 0.029). We conclude that consecutive cycles of ovarian stimulation with HMG are not detrimental and may, in fact, result in increased cycle fecundity compared to alternating stimulation cycles.
ISSN:0268-1161
1460-2350
DOI:10.1093/oxfordjournals.humrep.a137775