Treatment of lupus patients with a tolerogenic peptide, hCDR1 (Edratide): Immunomodulation of gene expression

Systemic lupus erythematosus (SLE) is an autoimmune disorder characterized by dysregulation of cytokines, apoptosis, and B- and T-cell functions. The tolerogenic peptide, hCDR1 (Edratide), ameliorated the clinical manifestations of murine lupus via down-regulation of pro-inflammatory cytokines and a...

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Bibliographic Details
Published in:Journal of autoimmunity 2009-08, Vol.33 (1), p.77-82
Main Authors: Sthoeger, Zev M., Sharabi, Amir, Molad, Yair, Asher, Ilan, Zinger, Heidy, Dayan, Molly, Mozes, Edna
Format: Article
Language:English
Subjects:
Adult
Allergy and Immunology
Antibodies, Monoclonal - administration & dosage
Apoptosis - drug effects
Biological and medical sciences
Caspases - genetics
Caspases - immunology
Caspases - metabolism
Complementarity Determining Regions - immunology
Cytokines - genetics
Cytokines - immunology
Cytokines - metabolism
Disease Progression
Female
Forkhead Transcription Factors - genetics
Forkhead Transcription Factors - immunology
Forkhead Transcription Factors - metabolism
Fundamental and applied biological sciences. Psychology
Fundamental immunology
Gene Expression Regulation - immunology
Humans
Immunomodulation of gene expression
Immunotherapy
Leukocytes, Mononuclear - drug effects
Leukocytes, Mononuclear - immunology
Leukocytes, Mononuclear - metabolism
Leukocytes, Mononuclear - pathology
Lupus Erythematosus, Systemic - blood
Lupus Erythematosus, Systemic - immunology
Lupus Erythematosus, Systemic - physiopathology
Lupus Erythematosus, Systemic - therapy
Lupus patients
Male
Medical sciences
Middle Aged
Peptide Fragments - administration & dosage
Peptide-based treatment
Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis
Self Tolerance - immunology
Severity of Illness Index
Systemic lupus erythematosus
Tolerogenic peptide
Transforming Growth Factor beta - genetics
Transforming Growth Factor beta - immunology
Transforming Growth Factor beta - metabolism
Treatment Outcome
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