Entorhinal Cortex Lesions Disrupt the Transition Between the Use of Intra- and Extramaze Cues for Navigation in the Water Maze

This study with rats examined the effects of excitotoxic lesions to the entorhinal cortex (EC) and hippocampus (HPC) on using extramaze and intramaze cues to navigate to a hidden platform in a water maze. HPC lesions resulted in a disruption to the use of extramaze cues, but not intramaze cues, wher...

Full description

Saved in:
Bibliographic Details
Published in:Behavioral neuroscience 2003-06, Vol.117 (3), p.588-595
Main Authors: Oswald, C. J. P, Bannerman, D. M, Yee, B. K, Rawlins, J. N. P, Honey, R. C, Good, M
Format: Article
Language:English
Subjects:
Anatomical correlates of behavior
Animal
Animal cognition
Animals
Behavioral psychophysiology
Biological and medical sciences
Brain
Cerebral Cortex
Cues
Entorhinal Cortex
Entorhinal Cortex - physiology
Fundamental and applied biological sciences. Psychology
Hippocampus
Laboratory animals
Maze Learning
Maze Learning - physiology
Neurology
Psychology. Psychoanalysis. Psychiatry
Psychology. Psychophysiology
Rats
Reaction Time - physiology
Rodents
Spatial Ability
Spatial Behavior - physiology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:This study with rats examined the effects of excitotoxic lesions to the entorhinal cortex (EC) and hippocampus (HPC) on using extramaze and intramaze cues to navigate to a hidden platform in a water maze. HPC lesions resulted in a disruption to the use of extramaze cues, but not intramaze cues, whereas EC lesions had no effect on the use of these cues when they were encountered for the first time. However, prior navigation training in which 1 type of cue was relevant disrupted navigation with the other type in rats with EC lesions. Results show that the EC contributes to the processing of spatial information, but that this contribution is most apparent when there is a conflict between 2 sources of navigational cues in the water maze.
ISSN:0735-7044
1939-0084
DOI:10.1037/0735-7044.117.3.588