Rheologic properties of sinonasal mucus in patients with chronic sinusitis

Mucociliary clearance is impaired in chronic rhinosinusitis (CRS). Clearance of sinonasal secretions is influenced by its rheological properties. The purpose of this study was to describe the rheological properties of sinonasal mucus in patients with CRS and correlate them with disease severity. Twe...

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Bibliographic Details
Published in:American journal of rhinology & allergy 2010-01, Vol.24 (1), p.1-5
Main Authors: Saito, David M, Innes, Anh L, Pletcher, Steven D
Format: Article
Language:English
Subjects:
Adult
Aged
Chronic Disease
Disease Progression
Female
Humans
Male
Middle Aged
Mucociliary Clearance
Mucus - metabolism
Paranasal Sinuses - diagnostic imaging
Paranasal Sinuses - metabolism
Prognosis
Radiography
Rheology - instrumentation
Rheology - methods
Rhinitis - diagnosis
Rhinitis - physiopathology
Sinusitis - diagnosis
Sinusitis - physiopathology
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Summary:Mucociliary clearance is impaired in chronic rhinosinusitis (CRS). Clearance of sinonasal secretions is influenced by its rheological properties. The purpose of this study was to describe the rheological properties of sinonasal mucus in patients with CRS and correlate them with disease severity. Twenty-three adult subjects with CRS underwent collection of sinonasal secretions. Samples were analyzed using the AR2000 cone and plate rheometer (TA Instruments, New Castle, DE) to determine the dynamic viscosity and elasticity. These properties were used to calculate mucus clearance indices. All patients completed the Sinonasal Outcome Test (SNOT-20). Recent sinus computed tomography (CT) scans were electronically reviewed and scored according to the Lund-McKay staging system. The mean dynamic elasticity and viscosity of sinus mucus at 1 Hz were 78.24 +/- 103.4 Pa and 22.09 +/- 29.62 Pa, respectively. The mean elasticity and viscosity values at 10 Hz were 118.9 +/- 155.5 Pa and 32.36 +/- 45.58 Pa, respectively. Three indices of disease severity (SNOT-20 score, Lund-McKay score, and nasal polyps) correlated with increased mucus viscoelasticity and/or worsened mucociliary clearance indices (MCIs). This study establishes the range of rheological properties of sinonasal mucus in patients with CRS and suggests an association between disease severity and MCIs.
ISSN:1945-8924
1945-8932
DOI:10.2500/ajra.2010.24.3420