Comparative study of skin sebum and elasticity level in patients with sulfur mustard-induced dermatitis and healthy controls

Background: Sulfur mustard (SM) – a chemical agent – has both acute and chronic effects on skin. Xerosis, which is deemed to be due to the damage of hydrolipidic barrier of the skin, is the most common complaint of veterans exposed to the chemical. This study was designed to evaluate skin sebum and...

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Published in:Skin research and technology 2010-05, Vol.16 (2), p.237-242
Main Authors: Davoudi, Seyyed Masoud, Sadr, Bardia, Hayatbakhsh, Mohammad R., Keshavarz, Saeed, Shohrati, Majid, Naghizadeh, Mohammad Mehdi, Babakoohi, Shahab, Rashighi-Firouzabadi, Mehdi, Firooz, Alireza
Format: Article
Language:English
Subjects:
Adult
Chemical Warfare Agents - toxicity
dermatitis
Elasticity - drug effects
Forehead
Hand Dermatoses - chemically induced
Hand Dermatoses - metabolism
Hand Dermatoses - pathology
Humans
Ichthyosis - chemically induced
Ichthyosis - metabolism
Ichthyosis - pathology
Iran
Male
Middle Aged
Mustard Gas - toxicity
Sebum - metabolism
Skin - drug effects
Skin - metabolism
Skin - pathology
skin elasticity
skin sebum
sulfur mustard
Thorax
Time Factors
Warfare
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Summary:Background: Sulfur mustard (SM) – a chemical agent – has both acute and chronic effects on skin. Xerosis, which is deemed to be due to the damage of hydrolipidic barrier of the skin, is the most common complaint of veterans exposed to the chemical. This study was designed to evaluate skin sebum and elasticity in veterans with a history of SM contact. Methods: Three hundred and ten subjects were enrolled in this study and were divided into four groups: SM‐exposed patients with current skin lesions (n=87); SM‐exposed patients without skin lesions (n=71); patients with dermatitis (n=78); and normal controls (n=74). The skin sebum and elasticity were measured in four areas (forehead, suprasternal, palm and back of the hands) using a Sebumeter and a Reviscometer. Results: Skin sebum was higher in participants who presented with dermatitis and had history of contact with SM than others; the difference was only statistically significant on the forehead. There was no significant difference in the skin elasticity between the four groups. Conclusion: While SM may increase skin sebum in long term, there is no evidence that it has a substantial effect on skin elasticity.
ISSN:0909-752X
1600-0846
DOI:10.1111/j.1600-0846.2009.00418.x