Complications affecting preterm neonates from 1991 to 2006: what have we gained?

Aim:  In this study, we determined whether outcome of preterm neonates has improved over a period of 16 years. Study design:  Inborn neonates with a gestational age of 25.0–29.9 weeks were included. Patients with severe congenital malformations were excluded. Mortality and morbidity (chronic lung di...

Full description

Saved in:
Bibliographic Details
Published in:Acta Paediatrica 2010-03, Vol.99 (3), p.354-358
Main Authors: Groenendaal, F, Termote, JUM, Van Der Heide-Jalving, M, Van Haastert, IC, De Vries, LS
Format: Article
Language:English
Subjects:
Biological and medical sciences
Complications
General aspects
Gestational Age
Humans
Infant Mortality - trends
Infant, Newborn
Infant, Premature
Infant, Premature, Diseases - epidemiology
Infant, Premature, Diseases - mortality
Infant, Premature, Diseases - therapy
Intensive Care Units, Neonatal
Intensive Care, Neonatal
Medical sciences
Miscellaneous
Netherlands - epidemiology
Neurodevelopment
Outcome Assessment (Health Care)
Prematurity
Public health. Hygiene
Public health. Hygiene-occupational medicine
Trends
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Aim:  In this study, we determined whether outcome of preterm neonates has improved over a period of 16 years. Study design:  Inborn neonates with a gestational age of 25.0–29.9 weeks were included. Patients with severe congenital malformations were excluded. Mortality and morbidity (chronic lung disease; CLD, intraventricular haemorrhage: IVH grade III or IV, cystic periventricular leukomalacia: cPVL, perforated necrotizing enterocolitis: NEC, severe retinopathy of prematurity needing surgery: ROP and cerebral palsy: CP) were compared in three periods (period 1: 1991–1996 n = 434; period 2: 1997–2001 n = 356; period 3: 2002–2006 n = 422). Results:  Infant mortality decreased from 15.2% to 10.9%. CLD did not differ significantly between periods (14.1–14.8%). Perforated NEC decreased from 2.8% to 1.6%. IVH grade III and IV both remained at 5.7% in period 3, whereas cPVL decreased significantly from 4.5% to 1.6%. Cerebral palsy decreased from 5.8% to 3.5% in period 3. Two neonates in each period were in need of surgery for ROP. Conclusion:  Inborn preterm patients showed an improved survival and a significant reduction in cPVL and CP. Perforated NEC showed a trend to decrease. CLD and IVH grade III and IV remain a matter of concern.
ISSN:0803-5253
1651-2227
DOI:10.1111/j.1651-2227.2009.01648.x