Automated Heart-Type Fatty Acid-Binding Protein Assay for the Early Diagnosis of Acute Myocardial Infarction

We compared an automated quantitative heart-type fatty acid-binding protein (H-FABP) assay with other cardiac-marker assays to examine its usefulness as an early diagnostic marker of acute myocardial infarction (AMI). Serum samples for cardiac troponin T (cTnT), creatine kinase-MB isozyme (CK-MB), m...

Full description

Saved in:
Bibliographic Details
Published in:American journal of clinical pathology 2010-07, Vol.134 (1), p.157-162
Main Authors: KIM, Yeongsic, KIM, Hyunjung, KIM, Soo-Young, HAE KYUNG LEE, HI JEONG KWON, YONG GOO KIM, LEE, Jehoon, HYUNG MIN KIM, BYUNG HAK SO
Format: Article
Language:English
Subjects:
Biological and medical sciences
Cardiology. Vascular system
Chest Pain - blood
Chest Pain - diagnosis
Chest Pain - physiopathology
Coronary heart disease
Early Diagnosis
Electrocardiography
Fatty Acid Binding Protein 3
Fatty Acid-Binding Proteins - blood
Female
Heart
Humans
Immunoassay - methods
Investigative techniques, diagnostic techniques (general aspects)
Latex
Male
Medical sciences
Middle Aged
Myocardial Infarction - blood
Myocardial Infarction - diagnosis
Myocardial Infarction - physiopathology
Myocarditis. Cardiomyopathies
Myoglobin - blood
Nephelometry and Turbidimetry - methods
Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques
Predictive Value of Tests
ROC Curve
Time Factors
Troponin T - blood
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:We compared an automated quantitative heart-type fatty acid-binding protein (H-FABP) assay with other cardiac-marker assays to examine its usefulness as an early diagnostic marker of acute myocardial infarction (AMI). Serum samples for cardiac troponin T (cTnT), creatine kinase-MB isozyme (CK-MB), myoglobin, and H-FABP were obtained from 64 patients with AMI and 53 patients with other conditions (control group). H-FABP was measured by using 2 immunoassays, the H-FABP enzyme-linked immunosorbent assay (ELISA; Biocheck, Foster City, CA) and the H-FABP latex turbidimetric immunoassay (LTIA; HBI, Anyang, Korea). Sensitivities of assays for cTnT, CK-MB, myoglobin, H-FABP (by ELISA), H-FABP (by LTIA), and electrocardiogram (ECG) for the diagnosis of AMI at hospital admission were 39.1%, 59.4%, 64.1%, 68.7%, 70.3%, and 54.7%, respectively. Specificities of cTnT, CK-MB, myoglobin, H-FABP (by ELISA), H-FABP (by LTIA), and ECG were 98.1%, 71.7%, 81.1%, 77.4%, 90.6%, and 92.5%, respectively. The automated H-FABP (by LTIA) is superior to cTnT, CK-MB, myoglobin, and H-FABP (by ELISA) tests for the diagnosis of AMI in patients admitted within 4 hours from the onset of chest pain.
ISSN:0002-9173
1943-7722
DOI:10.1309/AJCP0F6AXRCJMQQG