Dehydroabietic acid, a diterpene, improves diabetes and hyperlipidemia in obese diabetic KK-Ay mice

Terpenoids, which are contained in a large number of dietary and herbal plants, have many biological effects. In this study, the effects of dehydroabietic acid (DAA), a diterpene, on glucose and lipid metabolism were examined using obese diabetic KK‐Ay mice. We showed here that DAA treatment decreas...

Full description

Saved in:
Bibliographic Details
Published in:BioFactors (Oxford) 2009-09, Vol.35 (5), p.442-448
Main Authors: Kang, Min-Sook, Hirai, Shizuka, Goto, Tsuyoshi, Kuroyanagi, Kayo, Kim, Young-II, Ohyama, Kana, Uemura, Taku, Lee, Joo-Young, Sakamoto, Tomoya, Ezaki, Yoichiro, Yu, Rina, Takahashi, Nobuyuki, Kawada, Teruo
Format: Article
Language:English
Subjects:
Adiponectin - biosynthesis
Animals
Blood Glucose - metabolism
Chemokine CCL2 - biosynthesis
dehydroabietic acid
Diabetes Mellitus, Type 2 - complications
Diabetes Mellitus, Type 2 - drug therapy
Diterpenes, Abietane - therapeutic use
Hyperlipidemias - drug therapy
inflammation
Insulin - blood
Macrophages - drug effects
Macrophages - physiology
metabolic syndrome
Mice
Mice, Obese
Obesity - complications
PPARs
Triglycerides - blood
Tumor Necrosis Factor-alpha - biosynthesis
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Terpenoids, which are contained in a large number of dietary and herbal plants, have many biological effects. In this study, the effects of dehydroabietic acid (DAA), a diterpene, on glucose and lipid metabolism were examined using obese diabetic KK‐Ay mice. We showed here that DAA treatment decreased not only plasma glucose and insulin levels but also plasma triglyceride (TG) and hepatic TG levels. To examine the mechanism underlying the effects of DAA, the production of inflammatory cytokines was measured. It was shown that the DAA treatment suppressed the production of monocyte chemoattractant protein‐1 (MCP‐1) and tumor necrosis factor‐α (TNFα) (proinflammatory cytokines) and increased that of adiponectin (an anti‐inflammatory cytokine). As a result of the changes in the production of inflammatory cytokines caused by the DAA treatment, the accumulation of macrophages in adipose tissues was reduced. These results indicate that treatment with DAA improves the levels of plasma glucose, plasma insulin, plasma TG, and hepatic TG through the decrease in the macrophage infiltration into adipose tissues, suggesting that DAA is a useful food‐derived compound for treating obesity‐related diseases. © 2009 International Union of Biochemistry and Molecular Biology, Inc.
ISSN:0951-6433
1872-8081
DOI:10.1002/biof.58