IgA Immune Responses Against Acetaldehyde Adducts and Biomarkers of Alcohol Consumption in Patients with IgA Glomerulonephritis

Background:  The pathogenesis of IgA glomerulonephritis (IgAGN) involves intense deposition of IgAs within the glomerulus. Although previous studies have shown that heavy drinking frequently leads to the generation of IgA antibodies against neo‐antigens induced by ethanol metabolites and tissue depo...

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Published in:Alcoholism, clinical and experimental research clinical and experimental research, 2009-07, Vol.33 (7), p.1231-1237
Main Authors: Kaartinen, Kati, Niemelä, Onni, Syrjänen, Jaana, Alatalo, Päivikki, Pörsti, Ilkka, Harmoinen, Aimo, Pasternack, Amos, Huhtala, Heini, Mustonen, Jukka
Format: Article
Language:English
Subjects:
Acetaldehyde
Acetaldehyde - immunology
Adolescent
Adult
Aged
Aged, 80 and over
Alcohol
Alcohol Drinking - immunology
Alcoholism and acute alcohol poisoning
Biological and medical sciences
Biomarkers - blood
CDT
DNA Adducts - immunology
Female
Follow-Up Studies
Glomerulonephritis
Glomerulonephritis, IGA - diagnosis
Glomerulonephritis, IGA - immunology
Humans
Immunoglobulin A
Immunoglobulin A - biosynthesis
Immunoglobulin A - blood
Kidney
Male
Medical sciences
Middle Aged
Nephrology. Urinary tract diseases
Nephropathies. Renovascular diseases. Renal failure
Toxicology
Young Adult
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Summary:Background:  The pathogenesis of IgA glomerulonephritis (IgAGN) involves intense deposition of IgAs within the glomerulus. Although previous studies have shown that heavy drinking frequently leads to the generation of IgA antibodies against neo‐antigens induced by ethanol metabolites and tissue deposition of IgAs, the associations between alcohol consumption, IgA immune responses, and kidney disease have not been examined. Methods:  A total of 158 IgAGN patients (96 men, 62 women) were classified as abstainers (n = 38), moderate drinkers (n = 114), and heavy drinkers (n = 6) based on self‐reported alcohol consumption. The reference population included 143 individuals (99 men, 44 women) who were either apparently healthy abstainers (n = 31), moderate drinkers (n = 43), or heavy drinkers devoid of liver disease (n = 69). The assessments included various biomarkers of alcohol consumption: carbohydrate‐deficient transferrin (CDT), glutamyl transferase, γ‐CDT (combination of GGR and CDT), mean corpuscular volume (MCV), tests for liver and kidney function, serum immunoglobulin A (IgA), and specific IgA antibodies against acetaldehyde–protein adducts. Results:  In male IgAGN patients, drinking status was significantly associated with MCV, p 
ISSN:0145-6008
1530-0277
DOI:10.1111/j.1530-0277.2009.00947.x