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Low mRNA expression of the apoptosis-related genes CASP3, CASP8, and FAS is associated with low induction treatment response in childhood acute lymphoblastic leukemia (ALL)

Background Defects in apoptosis signaling have been considered to be responsible for treatment failure in many types of cancer, although with controversial results. The objective of the present study was to assess the expression profile of key apoptosis‐related genes in terms of clinical and biologi...

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Published in:Pediatric blood & cancer 2010-07, Vol.55 (1), p.100-107
Main Authors: Mata, Juliana F., Silveira, Vanessa S., Mateo, Elvis C., Cortez, Maria A.A., Queiroz, Rosane G.P., Yunes, José Andrés, Lee, Maria Lúcia M., Toledo, Sílvia R.C., Petrilli, Antonio Sérgio, Brandalise, Silvia R., Tone, Luiz G., Scrideli, Carlos A.
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Language:English
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Summary:Background Defects in apoptosis signaling have been considered to be responsible for treatment failure in many types of cancer, although with controversial results. The objective of the present study was to assess the expression profile of key apoptosis‐related genes in terms of clinical and biological variables and of the survival of children with acute lymphoblastic leukemia (ALL). Procedure The levels of mRNA expression of the apoptosis‐related genes CASP3, CASP8, CASP9, FAS, and BCL2 were analyzed by quantitative real‐time PCR in consecutive samples from 139 consecutive children with ALL at diagnosis treated by the Brazilian protocol (GBTLI‐ALL 99). Gene expression levels and clinical and biological features were compared by the Mann–Whitney test. Event‐free survival (EFS) was calculated by Kaplan–Meier plots and log‐rank test. Results A significant correlation was detected between CASP3, CASP8, CASP9, and FAS expression levels (P 
ISSN:1545-5009
1545-5017
1545-5017
DOI:10.1002/pbc.22463