The distribution of 13 killer-cell immunoglobulin-like receptor loci in UK blood donors from three ethnic groups

Summary Killer‐cell immunoglobulin‐like receptors (KIRs) can inhibit the killing activity of natural killer (NK) cells if they interact with their ligand, class I HLA. Using a modified polymerase chain reaction–sequence‐specific primers (PCR‐SSP) method for typing KIRs using genomic DNA, we compared...

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Bibliographic Details
Published in:European journal of immunogenetics 2003-06, Vol.30 (3), p.213-221
Main Authors: Cook, M. A., Moss, P. A. H., Briggs, D. C.
Format: Article
Language:English
Subjects:
Blood Donors
Ethnic Groups
European Continental Ancestry Group - genetics
Gene Frequency
Humans
India
Linkage Disequilibrium
Receptors, Immunologic - genetics
Receptors, KIR
Receptors, KIR2DL1
Receptors, KIR3DS1
Reproducibility of Results
United Kingdom - ethnology
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Summary:Summary Killer‐cell immunoglobulin‐like receptors (KIRs) can inhibit the killing activity of natural killer (NK) cells if they interact with their ligand, class I HLA. Using a modified polymerase chain reaction–sequence‐specific primers (PCR‐SSP) method for typing KIRs using genomic DNA, we compared KIR frequencies in three ethnic populations drawn from UK blood donors. We found a significantly lower frequency of the inhibitory KIRs KIR2DS1 and 3DS1 in Afro‐Caribbean blood donors. Despite this, there was a (non‐significant) increase in the B haplotype in Afro‐Caribbean and Indian Asian donors. Some donors from each group tested negative for all non‐inhibitory KIRs. In addition, we describe several new KIR profiles. Analysis of linkage disequilibrium was consistent with previously published findings.
ISSN:0960-7420
1365-2370
DOI:10.1046/j.1365-2370.2003.00394.x