Epileptic, organic and genetic vulnerabilities for timing of the development of interictal psychosis

Age at the first psychotic episode and an interval between the onset of epilepsy and that of psychosis reflect developmental processes of interictal psychosis. However, factors relating to these indices remain unknown. To identify clinical variables that are associated with the timing of the develop...

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Bibliographic Details
Published in:British journal of psychiatry 2010-03, Vol.196 (3), p.212-216
Main Authors: Adachi, Naoto, Akanuma, Nozomi, Ito, Masumi, Kato, Masaaki, Hara, Tsunekatsu, Oana, Yasunori, Matsuura, Masato, Okubo, Yoshiro, Onuma, Teiichi
Format: Article
Language:English
Subjects:
Adult
Age Factors
Age of Onset
Aged
Analysis of Variance
Developmental processes
Epilepsy
Epilepsy - complications
Epilepsy - genetics
Epilepsy - psychology
Female
Genetic Predisposition to Disease
Humans
Intellectual Disability - complications
Male
Middle Aged
Psychoses
Psychotic Disorders - etiology
Psychotic Disorders - genetics
Psychotic Disorders - psychology
Risk Factors
Seizure
Severity of Illness Index
Time Factors
Timing
Vulnerability
Young Adult
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Summary:Age at the first psychotic episode and an interval between the onset of epilepsy and that of psychosis reflect developmental processes of interictal psychosis. However, factors relating to these indices remain unknown. To identify clinical variables that are associated with the timing of the development of interictal psychosis. In 285 adults with epilepsy with interictal psychosis, effects of epileptic (epilepsy type), organic (intellectual functioning) and genetic (family history of psychosis) variables on timing of the development of psychosis were examined. The mean interval between the onset of epilepsy and that of psychosis was 14.4 years. Some psychosis occurred within a few years of the first seizure. Generalised epilepsy, normal intellectual function and a positive family history of psychosis were associated with early onset of psychosis. Early development of interictal psychosis in people with epilepsy may reflect other individual vulnerabilities to psychosis rather than epilepsy-related damage.
ISSN:0007-1250
1472-1465
DOI:10.1192/bjp.bp.108.056721