Acid-base properties of functionalised tripodal polyamines and their interaction with nucleotides and nucleic acids

Novel, highly positively charged tripodal polyamines with appended heterocyclic moieties revealed an intriguing panel of protonation species within the biologically relevant range. Studied compounds bind nucleotide monophosphates by mostly electrostatic interactions but only the imidazole analogue s...

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Bibliographic Details
Published in:Organic & biomolecular chemistry 2010-01, Vol.8 (11), p.2567-2574
Main Authors: Sornosa-Ten, Alejandra, Albelda, M Teresa, Frías, Juan C, García-España, Enrique, Llinares, José M, Budimir, Ana, Piantanida, Ivo
Format: Article
Language:English
Subjects:
Hydrogen-Ion Concentration
Magnetic Resonance Spectroscopy
Molecular Structure
Nucleic Acids - chemistry
Nucleotides - chemistry
Polyamines - chemistry
Protons
Solutions - chemistry
Thermodynamics
Water - chemistry
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Summary:Novel, highly positively charged tripodal polyamines with appended heterocyclic moieties revealed an intriguing panel of protonation species within the biologically relevant range. Studied compounds bind nucleotide monophosphates by mostly electrostatic interactions but only the imidazole analogue showed selectivity toward UMP in respect to other nucleotides. Strong binding of all the studied compounds to both ds-DNA and ds-RNA is to some extent selective toward the latter, showing rather rare RNA over DNA preference.
ISSN:1477-0520
1477-0539
DOI:10.1039/c000124d