Serum zinc is decreased in Alzheimer's disease and serum arsenic correlates positively with cognitive ability

Zinc, copper, and iron aggregate Aβ and accumulate in Alzheimer's disease (AD) plaques. Some metals are increased in AD vs. control serum. The authors examined levels of 12 metals in serum of 44 AD and 41 control subjects. Zinc decreased from 12.3 to 10.9 μmol/L (means, p = 0.0007). Arsenic pos...

Full description

Saved in:
Bibliographic Details
Published in:Biometals 2010-02, Vol.23 (1), p.173-179
Main Authors: Baum, Larry, Chan, Iris Hiu Shuen, Cheung, Stanley Kwok-Kuen, Goggins, William B, Mok, Vincent, Lam, Linda, Leung, Vivian, Hui, Elsie, Ng, Chelsia, Woo, Jean, Chiu, Helen Fung Kum, Zee, Benny Chung-Ying, Cheng, William, Chan, Ming-Houng, Szeto, Samuel, Lui, Victor, Tsoh, Joshua, Bush, Ashley I, Lam, Christopher Wai Kei, Kwok, Timothy
Format: Article
Language:English
Subjects:
Aged
Alzheimer Disease - blood
Alzheimer's disease
Arsenic
Arsenic - blood
Biochemistry
Biomedical and Life Sciences
Cell Biology
Cognition
Cognition & reasoning
Cognitive ability
Correlation analysis
Female
Humans
Life Sciences
Male
Medicine/Public Health
Microbiology
Pharmacology/Toxicology
Plant Physiology
Seafood
Zinc
Zinc - blood
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Zinc, copper, and iron aggregate Aβ and accumulate in Alzheimer's disease (AD) plaques. Some metals are increased in AD vs. control serum. The authors examined levels of 12 metals in serum of 44 AD and 41 control subjects. Zinc decreased from 12.3 to 10.9 μmol/L (means, p = 0.0007). Arsenic positively correlated with Mini-Mental State Examination score (p < 0.0001). Zinc deposition in brain amyloid might deplete zinc from other body compartments, such as serum. The arsenic correlation might be caused by the major contribution of seafood consumption to intake of both arsenic and docosahexaenoic acid, of which the latter may delay AD.
ISSN:0966-0844
1572-8773
DOI:10.1007/s10534-009-9277-5