Why we need semisolid decalcification system in bone tissue engineering? A story begins with honeycomb

Summary The repair of large segmental bone defects remains a tough problem disturbing surgeons and researchers. Bone tissue engineering brings some new sight in this field. However, it has not been effectively applied in clinics, for the reason that the involved mechanism is not well understood. Thu...

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Bibliographic Details
Published in:Medical hypotheses 2010-08, Vol.75 (2), p.225-228
Main Authors: Jiang, Shan, Jiang, Qian-li, Zhang, Yang, Li, Le, Zhao, Pei-ran, Pan, Yan-fei, Chang, Wei, Liu, Luan-jia, Pei, Guo-xian
Format: Article
Language:English
Subjects:
Biocompatible Materials
Bone and Bones - physiology
Humans
Internal Medicine
Models, Biological
Osteogenesis
Tissue Engineering - methods
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Summary:Summary The repair of large segmental bone defects remains a tough problem disturbing surgeons and researchers. Bone tissue engineering brings some new sight in this field. However, it has not been effectively applied in clinics, for the reason that the involved mechanism is not well understood. Thus, we need to know the osteogenesis process of the tissue-engineered bone including distribution, proliferation and interaction among seed cells pre-inoculated in biomaterials as well as the function of surrounding tissues. As a matter of fact, the tissue-engineered bone or the biomaterials are solid and opaque, which makes the study difficult. Here, inspired by the structure of honeycomb and amber, we hypothesize a semisolid decalcification protocol to solve this problem.
ISSN:0306-9877
1532-2777
DOI:10.1016/j.mehy.2010.02.026