variable plasma quercetin response to 12-week quercetin supplementation in humans

Background/Objectives: Quercetin supplementation results in a variable plasma quercetin response in humans. The purpose of this study was to determine whether this variance is related to gender, age, body mass index (BMI), and other demographic and lifestyle factors. Subjects/Methods: Subjects (N=10...

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Published in:European journal of clinical nutrition 2010-07, Vol.64 (7), p.692-697
Main Authors: Jin, F, Nieman, D.C, Shanely, R.A, Knab, A.M, Austin, M.D, Sha, W
Format: Article
Language:English
Subjects:
631/92/436/1729
692/700/459/1994
Adolescent
Adult
Age
Aged
Aged, 80 and over
Bioavailability
Blood
blood plasma
Body Constitution
Body mass index
Body size
Clinical Nutrition
Demographics
Diet
Dietary Supplements
dose response
Dose-Response Relationship, Drug
Double-Blind Method
Epidemiology
Female
Food groups
Food intake
Gender
gender differences
Health aspects
human nutrition
Humans
Internal Medicine
lifestyle
Male
Medicine
Medicine & Public Health
men
Metabolic Diseases
Metabolism
Middle Aged
nutrition physiology
Nutrition research
original-article
Physical fitness
Physiological aspects
phytochemicals
Placebos
Plant Extracts - administration & dosage
Plant Extracts - blood
Plant Extracts - pharmacology
Plasma
Public Health
Quercetin
Quercetin - administration & dosage
Quercetin - blood
Quercetin - pharmacology
randomized clinical trials
sociodemographic characteristics
women
Young Adult
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Sha, W
description Background/Objectives: Quercetin supplementation results in a variable plasma quercetin response in humans. The purpose of this study was to determine whether this variance is related to gender, age, body mass index (BMI), and other demographic and lifestyle factors. Subjects/Methods: Subjects (N=1002, ages 18–85 years, 60% female and 40% male) were recruited from the community and randomized to one of three groups, with supplements administered using double-blinded procedures: Q-500 (500 mg/day), Q-1000 (1000 mg/day), or placebo. Subjects ingested two soft chew supplements twice daily during the 12-week study. Fasting blood samples were obtained pre- and post-study, analyzed for plasma quercetin, and then compared between and within groups by gender, age group (
doi_str_mv 10.1038/ejcn.2010.91
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The purpose of this study was to determine whether this variance is related to gender, age, body mass index (BMI), and other demographic and lifestyle factors. Subjects/Methods: Subjects (N=1002, ages 18–85 years, 60% female and 40% male) were recruited from the community and randomized to one of three groups, with supplements administered using double-blinded procedures: Q-500 (500 mg/day), Q-1000 (1000 mg/day), or placebo. Subjects ingested two soft chew supplements twice daily during the 12-week study. Fasting blood samples were obtained pre- and post-study, analyzed for plasma quercetin, and then compared between and within groups by gender, age group (&lt;40, 40–59, and 60 years), BMI (&lt;25, 25–29.9, and 30 kg/m2), self-reported physical fitness level, and diet intake (food group servings). Results: Quercetin supplementation over 12 weeks caused a significant increase in overnight-fasted plasma quercetin, with a net increase of 332±21.0 and 516±30.8 μg/l for Q-500 and Q-1000 compared with 53.6±6.4 μg/l for placebo (interaction effect, P&lt;0.001). The increase in plasma quercetin was highly variable within each quercetin supplementation group, but was unrelated to age, gender, BMI, fitness levels, or diet intake. Conclusions: In summary, quercetin supplementation in doses of 500 and 1000 mg/day caused large but highly variable increases in plasma quercetin that were unrelated to demographic or lifestyle factors.</description><identifier>ISSN: 0954-3007</identifier><identifier>EISSN: 1476-5640</identifier><identifier>DOI: 10.1038/ejcn.2010.91</identifier><identifier>PMID: 20517329</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>631/92/436/1729 ; 692/700/459/1994 ; Adolescent ; Adult ; Age ; Aged ; Aged, 80 and over ; Bioavailability ; Blood ; blood plasma ; Body Constitution ; Body mass index ; Body size ; Clinical Nutrition ; Demographics ; Diet ; Dietary Supplements ; dose response ; Dose-Response Relationship, Drug ; Double-Blind Method ; Epidemiology ; Female ; Food groups ; Food intake ; Gender ; gender differences ; Health aspects ; human nutrition ; Humans ; Internal Medicine ; lifestyle ; Male ; Medicine ; Medicine &amp; Public Health ; men ; Metabolic Diseases ; Metabolism ; Middle Aged ; nutrition physiology ; Nutrition research ; original-article ; Physical fitness ; Physiological aspects ; phytochemicals ; Placebos ; Plant Extracts - administration &amp; dosage ; Plant Extracts - blood ; Plant Extracts - pharmacology ; Plasma ; Public Health ; Quercetin ; Quercetin - administration &amp; dosage ; Quercetin - blood ; Quercetin - pharmacology ; randomized clinical trials ; sociodemographic characteristics ; women ; Young Adult</subject><ispartof>European journal of clinical nutrition, 2010-07, Vol.64 (7), p.692-697</ispartof><rights>Macmillan Publishers Limited 2010</rights><rights>COPYRIGHT 2010 Nature Publishing Group</rights><rights>Macmillan Publishers Limited 2010.</rights><rights>Copyright Nature Publishing Group Jul 2010</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c606t-55e21fc7108748d04e1039db700a6b4a833e85e0d2a22d43307972eeebed54833</citedby><cites>FETCH-LOGICAL-c606t-55e21fc7108748d04e1039db700a6b4a833e85e0d2a22d43307972eeebed54833</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27922,27923</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20517329$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jin, F</creatorcontrib><creatorcontrib>Nieman, D.C</creatorcontrib><creatorcontrib>Shanely, R.A</creatorcontrib><creatorcontrib>Knab, A.M</creatorcontrib><creatorcontrib>Austin, M.D</creatorcontrib><creatorcontrib>Sha, W</creatorcontrib><title>variable plasma quercetin response to 12-week quercetin supplementation in humans</title><title>European journal of clinical nutrition</title><addtitle>Eur J Clin Nutr</addtitle><addtitle>Eur J Clin Nutr</addtitle><description>Background/Objectives: Quercetin supplementation results in a variable plasma quercetin response in humans. 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The purpose of this study was to determine whether this variance is related to gender, age, body mass index (BMI), and other demographic and lifestyle factors. Subjects/Methods: Subjects (N=1002, ages 18–85 years, 60% female and 40% male) were recruited from the community and randomized to one of three groups, with supplements administered using double-blinded procedures: Q-500 (500 mg/day), Q-1000 (1000 mg/day), or placebo. Subjects ingested two soft chew supplements twice daily during the 12-week study. Fasting blood samples were obtained pre- and post-study, analyzed for plasma quercetin, and then compared between and within groups by gender, age group (&lt;40, 40–59, and 60 years), BMI (&lt;25, 25–29.9, and 30 kg/m2), self-reported physical fitness level, and diet intake (food group servings). Results: Quercetin supplementation over 12 weeks caused a significant increase in overnight-fasted plasma quercetin, with a net increase of 332±21.0 and 516±30.8 μg/l for Q-500 and Q-1000 compared with 53.6±6.4 μg/l for placebo (interaction effect, P&lt;0.001). The increase in plasma quercetin was highly variable within each quercetin supplementation group, but was unrelated to age, gender, BMI, fitness levels, or diet intake. Conclusions: In summary, quercetin supplementation in doses of 500 and 1000 mg/day caused large but highly variable increases in plasma quercetin that were unrelated to demographic or lifestyle factors.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>20517329</pmid><doi>10.1038/ejcn.2010.91</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record>
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subjects 631/92/436/1729
692/700/459/1994
Adolescent
Adult
Age
Aged
Aged, 80 and over
Bioavailability
Blood
blood plasma
Body Constitution
Body mass index
Body size
Clinical Nutrition
Demographics
Diet
Dietary Supplements
dose response
Dose-Response Relationship, Drug
Double-Blind Method
Epidemiology
Female
Food groups
Food intake
Gender
gender differences
Health aspects
human nutrition
Humans
Internal Medicine
lifestyle
Male
Medicine
Medicine & Public Health
men
Metabolic Diseases
Metabolism
Middle Aged
nutrition physiology
Nutrition research
original-article
Physical fitness
Physiological aspects
phytochemicals
Placebos
Plant Extracts - administration & dosage
Plant Extracts - blood
Plant Extracts - pharmacology
Plasma
Public Health
Quercetin
Quercetin - administration & dosage
Quercetin - blood
Quercetin - pharmacology
randomized clinical trials
sociodemographic characteristics
women
Young Adult
title variable plasma quercetin response to 12-week quercetin supplementation in humans
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