The Effect of Posterior Distraction on Vertebral Growth in Immature Pigs: An Experimental Simulation of Growing Rod Technique

• Published in: Spine (Philadelphia, Pa. 1976) Pa. 1976), 2010-04, Vol.35 (7), p.730-733
• Main Authors: YILMAZ, Güney, HURI, Gazi, DEMIRKIRAN, Gökhan, DAGLIOGLU, Kenan, OZKAN, Cenk, ALANAY, Ahmet, ACAROGLU, Emre, YAZICI, Muharrem
• Format: Article
• Language: English
• Subjects: Animals; Biological and medical sciences; Bone Screws; Cerebrospinal fluid. Meninges. Spinal cord; Disease Models, Animal; Ear, auditive nerve, cochleovestibular tract, facial nerve: diseases, semeiology; Internal Fixators; Lumbar Vertebrae - diagnostic imaging; Lumbar Vertebrae - growth & development; Lumbar Vertebrae - surgery; Medical sciences; Nervous system (semeiology, syndromes); Neurology; Non tumoral diseases; Osteogenesis, Distraction - methods; Otorhinolaryngology. Stomatology; Radiography; Scoliosis - diagnostic imaging; Scoliosis - surgery; Swine; Thoracic Vertebrae - diagnostic imaging; Thoracic Vertebrae - growth & development; Thoracic Vertebrae - surgery; Treatment Outcome
• ISSN: 0362-2436; 1528-1159
• DOI: 10.1097/BRS.0b013e3181bcc3a3

Experimental study. The aim of this study is to evaluate the vertebral body growth under distraction forces in immature pigs treated with growing rod (GR) technique. Distraction forces applied on growth plate of appendicular skeleton stimulate longitudinal growth. However, the effect of distraction forces on axial skeletal growth has not been fully investigated yet. Twelve 10-week-old domestic pigs were used in this experimental model to simulate GR technique. Four of them were lost during postoperative period because of deep wound infection. Cranially T12-L1 and caudally L4-L5 vertebrae were instrumented by pedicle screws bilaterally, while L2 and L3 were skipped. Distraction between pedicle screws was applied at index surgery. The rods were then lengthened twice in a month interval. All subjects were evaluated with anteroposterior and lateral spinal radiograph before surgery, after surgery, and at the final follow-up. The vertebral body heights of distracted segments (HD = L2 and L3) and control segments (HC = T9, T10 and T11) were measured. Average vertebral body heights and the increase percentage in the vertebral body heights were compared among control segments and distracted segments. The preoperative vertebral body height was similar in 2 groups (preHC: 10.81 mm, n = 19, preHD: 11.27 mm, n = 16, P > 0.05). At the final follow-up, the average vertebral body height in distraction group was significantly higher than the control group (postHC: 17.03 mm, postHD: 18.58 mm, P < 0.05). The increase percentage in vertebral body height was higher in distracted segments, but there was no statistically significant difference between the 2 groups. The vertebral growth continues during GR instrumentation. Distraction forces might stimulate also apophyseal growth of axial skeleton.