Comparison of Right Ventricular Functional Response to Exercise in Hypertrophic Versus Idiopathic Dilated Cardiomyopathy

Although the biventricular nature of the disease has been confirmed by morphologic studies, information on right ventricular (RV) function in hypertrophic cardiomyopathy (HC) is lacking. The aim of the study was to hemodynamically characterize RV performance in HC versus idiopathic dilated cardiomyo...

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Bibliographic Details
Published in:The American journal of cardiology 2010, Vol.105 (1), p.116-121
Main Authors: Plehn, Gunnar, MD, Vormbrock, Julia, MD, Perings, Stefan, MD, Plehn, Alexander, MD, Meissner, Axel, MD, Butz, Thomas, MD, Trappe, Hans J., MD
Format: Article
Language:English
Subjects:
Biological and medical sciences
Cardiac Catheterization
Cardiology
Cardiology. Vascular system
Cardiomyopathy, Dilated - diagnosis
Cardiomyopathy, Dilated - physiopathology
Cardiomyopathy, Hypertrophic - diagnosis
Cardiomyopathy, Hypertrophic - physiopathology
Cardiovascular
Cells
Echocardiography, Doppler
Exercise
Exercise Test
Exercise Tolerance - physiology
Female
Heart
Humans
Male
Medical sciences
Middle Aged
Myocarditis. Cardiomyopathies
Patients
Prognosis
Retrospective Studies
Ventricular Function, Right - physiology
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Summary:Although the biventricular nature of the disease has been confirmed by morphologic studies, information on right ventricular (RV) function in hypertrophic cardiomyopathy (HC) is lacking. The aim of the study was to hemodynamically characterize RV performance in HC versus idiopathic dilated cardiomyopathy (IDC) during exercise. The hemodynamic data of 63 patients with HC who underwent hemodynamic exercise testing with thermodilution-derived assessment of RV ejection fraction were analyzed. The results were compared to a healthy control group (n = 20) and to patients with IDC (n = 86). The baseline RV ejection fraction was increased in the patients with HC compared to those with IDC (39 ± 10% vs 33 ± 12%; p = 0.002), but did not differ compared to controls (42 ± 7% vs 39 ± 10%; p = NS). An increase in end-diastolic volume from rest to exercise contributed to stroke volume augmentation in those with HC (121 ± 38 vs 136 ± 55 ml/m2 ; p = 0.01) and control subjects (116 ± 34 vs 138 ± 31 ml/m2 ; p = 0.002) but not in those with IDC (117 ± 47 vs 120 ± 52 ml/m2 ; p = NS). At peak exercise the RV ejection fraction in those with HC was reduced compared to that in the controls (45 ± 11% vs 59% ± 9%; p
ISSN:0002-9149
1879-1913
DOI:10.1016/j.amjcard.2009.08.662