Kaposi’s sarcoma of the head and neck: A review

Summary Important advances in Kaposi’s sarcoma (KS) knowledge have been achieved, but KS is still a dilemma. It is an angioproliferative disorder classified as an intermediate neoplasm due to the absence of conventional clinical features of malignancy, but at the moment, it remains unclear if KS cou...

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Bibliographic Details
Published in:Oral oncology 2010-03, Vol.46 (3), p.135-145
Main Authors: Ramírez-Amador, Velia, Anaya-Saavedra, Gabriela, Martínez-Mata, Guillermo
Format: Article
Language:English
Subjects:
Africa - epidemiology
AIDS
Biological and medical sciences
Brazil - epidemiology
Clonality
Dermatology
Female
Head and neck
Head and Neck Neoplasms - epidemiology
Head and Neck Neoplasms - pathology
Head and Neck Neoplasms - virology
Hematology, Oncology and Palliative Medicine
Herpesvirus 8, Human
HIV
HIV Infections - epidemiology
HIV Infections - pathology
HIV Infections - virology
HIV-1
Human herpesvirus-8
Humans
Kaposi’s sarcoma
Male
Medical sciences
Mediterranean Region - epidemiology
Oral
Otolaryngology
Otorhinolaryngology. Stomatology
Pathogenesis
Saliva
Sarcoma, Kaposi - epidemiology
Sarcoma, Kaposi - pathology
Sarcoma, Kaposi - virology
Therapy
Tumors
Tumors of the skin and soft tissue. Premalignant lesions
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Summary:Summary Important advances in Kaposi’s sarcoma (KS) knowledge have been achieved, but KS is still a dilemma. It is an angioproliferative disorder classified as an intermediate neoplasm due to the absence of conventional clinical features of malignancy, but at the moment, it remains unclear if KS could be considered a reactive proliferation of endothelial cells and spindle cells, a true malignancy or both. In this review, the authors address the main epidemiological, clinical, and biological features, of the five types of KS, with emphasis on KS affecting the head and neck region. Also, a revision is done in relation with transmission, the role of saliva, and the pathogenic events associated with human herpesvirus type-8 (HHV-8). Treatment options are revised, highlighting the need for future approaches focused on targeting signaling pathways.
ISSN:1368-8375
1879-0593
DOI:10.1016/j.oraloncology.2009.12.006