Allergic skin diseases

The skin is one of the largest immunologic organs and is affected by both external and internal factors, as well as innate and adaptive immune responses. Many skin disorders, such as atopic dermatitis, contact dermatitis, urticaria, angioedema, psoriasis, and autoimmune blistering disorders, are imm...

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Bibliographic Details
Published in:Journal of allergy and clinical immunology 2010-02, Vol.125 (2), p.S138-S149
Main Authors: Fonacier, Luz S., MD, Dreskin, Stephen C., MD, PhD, Leung, Donald Y.M., MD, PhD
Format: Article
Language:English
Subjects:
Adaptive Immunity
Allergens - immunology
Allergic contact dermatitis
Allergies
Allergy and Immunology
atopic dermatitis
autoimmune blistering disease
Dermatitis
Dermatitis, Allergic Contact - diagnosis
Dermatitis, Allergic Contact - immunology
Dermatitis, Allergic Contact - physiopathology
Dermatitis, Allergic Contact - therapy
Dermatitis, Atopic - genetics
Dermatitis, Atopic - immunology
Dermatitis, Atopic - therapy
Eczema
Environmental Exposure
Genetic Predisposition to Disease
Humans
Immune system
immune-mediated skin disorders
Immunity, Innate
Immunotherapy - trends
irritant contact dermatitis
Lymphocytes
Pemphigus - immunology
Pemphigus - physiopathology
Pemphigus - therapy
psoriasis
Psoriasis - diagnosis
Psoriasis - immunology
Psoriasis - physiopathology
Psoriasis - therapy
Skin diseases
Urticaria
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Summary:The skin is one of the largest immunologic organs and is affected by both external and internal factors, as well as innate and adaptive immune responses. Many skin disorders, such as atopic dermatitis, contact dermatitis, urticaria, angioedema, psoriasis, and autoimmune blistering disorders, are immune mediated. Most of these diseases are chronic, inflammatory, and proliferative, in which both genetic and environmental factors play important roles. These immunologic mechanisms might have implications for potential targets of future therapeutic interventions.
ISSN:0091-6749
1097-6825
DOI:10.1016/j.jaci.2009.05.039