Ion trap mass analysis at high pressure: an experimental characterization

In recent years, it has become increasingly interesting to understand the performance of mass spectrometers at pressures much higher than those employed with conventional operating conditions. This interest has been driven by several influences, including demand for the development of reduced-power...

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Bibliographic Details
Published in:Journal of mass spectrometry. 2010, Vol.45 (1), p.26-34
Main Authors: Song, Qingyu, Xu, Wei, Smith, Scott A, Gao, Liang, Chappell, William J, Cooks, R. Graham, Ouyang, Zheng
Format: Article
Language:English
Subjects:
Analytical chemistry
Atmospheric pressure
Barometric pressure
Buffers
Chemistry
Equipment Design
Exact sciences and technology
Filtering
Filtration
high pressure
instrumentation
Instruments, apparatus, components and techniques common to several branches of physics and astronomy
Ions - analysis
Mass spectrometers
Mass spectrometers and related techniques
mass spectrometry
Mass Spectrometry - instrumentation
Mass Spectrometry - methods
Miniature
Optimization
Physics
Pressure
Proteins - analysis
quadrupole ion trap (QIT)
rectilinear ion trap (RIT)
Spectrometric and optical methods
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Summary:In recent years, it has become increasingly interesting to understand the performance of mass spectrometers at pressures much higher than those employed with conventional operating conditions. This interest has been driven by several influences, including demand for the development of reduced-power miniature mass spectrometers, desire for improved ion transfer into and through mass spectrometers, enhanced-yield preparative mass separations, and mass filtering at the atmospheric pressure interface. In this study, an instrument was configured to allow for the performance characterization of a rectilinear ion trap (RIT) at pressures up to 50 mtorr with air used as the buffer gas. The mass analysis efficiency, mass resolution, isolation efficiency, and collision-induced dissociation (CID) efficiency were evaluated at pressures ranging from 1 to 50 mtorr. The extent of degradation of mass resolution, isolation efficiency and ion stability as functions of pressure were characterized. Also, the optimal resonance ejection conditions were obtained at various pressures. Operations at 50 mtorr demonstrated improved CID efficiency in addition to peak widths of 2 and 5 m/z units (full width at half-maximum, FWHM) for protonated caffeine (m/z 195) and Ultramark (m/z 1521) respectively. Copyright © 2009 John Wiley & Sons, Ltd.
ISSN:1076-5174
1096-9888
1096-9888
DOI:10.1002/jms.1684