Cell signaling and cancer-possible targets for therapy

Tumor progression involves the acquisition of properties which include growth‐factor independent cell proliferation, failure of inhibition by growth‐inhibitory signals, ability to invade surrounding tissues, and to evade apoptosis, etc. Characterization of the profile or molecular signature of the t...

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Bibliographic Details
Published in:Journal of cellular physiology 2010-05, Vol.223 (2), p.299-308
Main Author: Wenner, Charles E.
Format: Article
Language:English
Subjects:
Animals
Antineoplastic Agents - pharmacology
Antineoplastic Combined Chemotherapy Protocols - pharmacology
Apoptosis Regulatory Proteins - agonists
Apoptosis Regulatory Proteins - physiology
Cell Transformation, Neoplastic - drug effects
Cell Transformation, Neoplastic - genetics
Cell Transformation, Neoplastic - metabolism
Drug Design
Glycolysis - drug effects
Glycolysis - physiology
Growth Inhibitors - pharmacology
Humans
Intercellular Signaling Peptides and Proteins - physiology
Neoplasms - drug therapy
Neoplasms - genetics
Neoplasms - metabolism
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Summary:Tumor progression involves the acquisition of properties which include growth‐factor independent cell proliferation, failure of inhibition by growth‐inhibitory signals, ability to invade surrounding tissues, and to evade apoptosis, etc. Characterization of the profile or molecular signature of the tumor may permit the development of rational therapies that target the aberrant pathways. Rapidly growing tumor cells are usually associated with a high rates of glycolysis and in these cells, it may be advantageous to exploit this pathway which most likely is required for optimal synthetic needs. Combinatorial therapeutic agents which target the growth factor signal transduction pathways as well as apoptotic signaling pathways provide an opportunity for maximal therapeutic benefit. J. Cell. Physiol. 223: 299–308, 2010. © 2010 Wiley‐Liss, Inc.
ISSN:0021-9541
1097-4652
DOI:10.1002/jcp.22021