Elevated levels of collagen cross-link residues in gingival tissues and crevicular fluid of teeth with periodontal disease

Lysylpyridinoline (LP) and hydroxylysylpyridinoline (HP) are collagen cross‐link residues. Lysylpyridinoline is present in most tissues, whereas LP is present mainly in mineralized tissue. Both are elevated in tissue with increased collagen resorption. The purpose of this investigation was to assess...

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Bibliographic Details
Published in:European journal of oral sciences 2003-06, Vol.111 (3), p.198-202
Main Authors: Jepsen, Søren, Springer, Ingo N. G., Buschmann, Andreas, Hedderich, Jürgen, Açil, Yahya
Format: Article
Language:English
Subjects:
Adult
Amino Acids - analysis
Amino Acids - metabolism
Biomarkers
Case-Control Studies
Chromatography, High Pressure Liquid
Collagen - metabolism
collagen degradation
Dentistry
Female
Gingiva - chemistry
Gingival Crevicular Fluid - chemistry
Gingival crevicular fluid/analysis
Humans
Male
periodontal diagnosis
Periodontitis - metabolism
Periodontitis - pathology
periodontitis/therapy
pyridinoline cross-links
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Summary:Lysylpyridinoline (LP) and hydroxylysylpyridinoline (HP) are collagen cross‐link residues. Lysylpyridinoline is present in most tissues, whereas LP is present mainly in mineralized tissue. Both are elevated in tissue with increased collagen resorption. The purpose of this investigation was to assess if the concentrations of LP and HP are elevated in gingiva and gingival crevicular fluid (GCF) of teeth with advanced periodontitis (AP). We investigated human gingival biopsies of healthy teeth (n = 19) and teeth with AP (n = 43) in 49 individuals. Samples of GCF from 54 teeth with AP were collected in seven patients and compared with samples from 11 patients with experimentally induced gingivitis. Levels of LP and HP were measured by HPLC and fluorescence detection. Gingival concentrations of HP but not LP around teeth with advanced periodontitis were significantly elevated compared with teeth with healthy periodontium. While significant amounts of HP and LP were measurable in the GCF of teeth with AP, no HP and LP was identified 3 months following non‐surgical periodontal therapy of the teeth or in fluid from teeth subjected to experimentally induced gingivitis. Elevated concentrations of HP and LP in GCF may serve as indicators of ongoing destruction of periodontal tissues and alveolar bone in advanced periodontitis.
ISSN:0909-8836
1600-0722
DOI:10.1034/j.1600-0722.2003.00019.x